AGE AND CLINICAL IMMUNITY TO INFECTIONS WITH CHLAMYDIA-TRACHOMATIS
AGE AND CLINICAL IMMUNITY TO INFECTIONS WITH CHLAMYDIA-TRACHOMATIS
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DOI：
10.1097/00007435-199401000-00010
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发表时间：
1994-01-01
影响因子：
3.1
通讯作者：
JONES, RB
中科院分区：
文献类型：
--
作者：
ARNO, JN;KATZ, BP;JONES, RB
背景和目的：衣原体感染的患病率随着年龄的增长而下降，部分原因可能是由于免疫力的增强。这项研究的目的：确定年龄增加是否是衣原体感染减少的独立预测因素，以及衣原体特异性抗体效价和芽胞形成是否随年龄增加而增加。研究设计：对1984年1月至1989年8月所有沙眼衣原体培养患者的数据进行检验，并使用多元Logistic回归模型确定培养阳性的独立预测因素。对一组患者进行了抗衣原体抗体效价和衣原体特异性芽生作用的检测，以了解其与年龄的相关性。结果：在男性和女性中，年轻年龄是衣原体感染的独立预测因素，抗体滴度与年龄无关(n=245)，而芽生水平与年龄只有微弱的相关性(n=155)。结论：系统免疫检测不能反映与年龄相关的衣原体感染的保护作用。
Background and Objectives: The prevalence of chlamydial infection decreases with age possibly in part because of increasing immunity. Goal of this Study: To determine whether increased age is an independent predictor of decreased chlamydial infection and whether chlamydia-specific antibody titer and blastogenesis increase with age. Study Design: Data from all patients cultured for Chlamydia trachomatis between January 1984 and August 1989 were examined and multiple logistic regression models were used to identify the independent predictors of culture positivity. Antichlamydial antibody titer and chlamydia-specific blastogenesis were examined for a subset of patients for correlation with age. Results: Young age was found to be predictive of chlamydial infection independent of all factors examined in men and women, Antibody titers had no relation to age (n = 245) whereas the level of blastogenesis correlated only weakly with age (n = 155). Conclusions: Assays of systemic immunity do not reflect the protection from chlamydial infection associated with age.