Semaphorin7A: branching beyond axonal guidance and into immunity.

Semaphorin7A: branching beyond axonal guidance and into immunity.
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DOI:
10.1007/s12026-013-8460-5
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发表时间:
2013-12
影响因子:
4.4
通讯作者:
Iragavarapu-Charyulu, Vijaya
Iragavarapu-Charyulu, Vijaya
中科院分区:
医学4区
文献类型:
--
作者:
Garcia-Areas, Ramon;Libreros, Stephania;Iragavarapu-Charyulu, Vijaya

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脑信号蛋白是一个蛋白质家族,最初被描述为在轴突导向中的作用。现在的研究表明,semaphorins涵盖了神经系统以外的许多生理功能,包括免疫反应。Semaphorin7A(SEMA7A)属于“免疫”semaphorin组,并已被证明在调节免疫反应中起着至关重要的作用。本文就SEMA7A的结构、功能及其在天然免疫和获得性免疫中的作用作一综述。我们进一步描述了SEMA7A参与炎症性疾病及其在癌症中的紧急作用。
Semaphorins are a family of proteins that were originally described for their role in axonal guidance. Studies now show that semaphorins encompass many physiological functions outside of the nervous system, including immune responses. Semaphorin7A (SEMA7A) belongs to the “immune” semaphorin group and has been shown to play a crucial role in regulating immune responses. In this review, we discuss the structure and function of SEMA7A as well as its role of SEMA7A in innate and adaptive immunity. We further describe SEMA7A’s involvement in inflammatory disease and its emergent role in cancer.
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