Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth-restricted pregnancies
Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth-restricted pregnancies
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DOI：
10.1016/s0002-9378(96)70609-9
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发表时间：
1996-05-01
影响因子：
9.8
通讯作者：
Pardi, G
中科院分区：
文献类型：
--
作者：
Cetin, I;Ronzoni, S;Pardi, G
目的：我们的目的是确定是否母体氨基酸浓度的变化在怀孕期间在怀孕与宫内生长受限在正常妊娠，并验证这些变化是否与变化的胎儿母亲的差异。在5名非妊娠妇女、11名妊娠中期妇女和10名妊娠晚期妇女中测量了适合胎龄胎儿的氨基酸浓度，23例宫内生长受限孕妇。在胎儿采血时测量脐静脉氨基酸。宫内生长受限的严重程度进行了评估多普勒测速仪和胎儿心率和氧合和酸碱平衡的评价。结果：在正常孕妇的母亲浓度的大多数氨基酸显着降低，在第二和第三孕期与非妊娠妇女相比。在宫内生长受限的母亲浓度的大多数必需氨基酸显着高于适合胎龄妊娠。这一观察结果，再加上胎儿氨基酸浓度较低的宫内生长受限，导致显着降低母胎差异。结论：与非妊娠妇女相比，正常妊娠妇女的氨基酸浓度显著降低，而在宫内生长受限的母体氨基酸减少较少。宫内生长受限的胎儿-母体浓度差异显著降低，与严重程度无关。
OBJECTIVES: Our purpose was to determine whether maternal amino acid concentration changes during gestation in pregnancies with intrauterine growth restriction as in normal pregnancies and to verify whether these changes are related to changes in fetal-maternal differences.STUDY DESIGN: Amino acid concentrations were measured in 5 nonpregnant women, in 11 second-trimester and 10 third-trimester pregnant women with appropriate-for-gestational-age fetuses, and in 23 pregnant women with intrauterine growth restriction. Umbilical venous amino acids were measured at the time of fetal blood sampling. The severity of intrauterine growth restriction was assessed by Doppler velocimetry and fetal heart rate and by evaluation of oxygenation and acid-base balance.RESULTS: In normal pregnant women the maternal concentration of most amino acids was significantly lower in both the second and third trimesters compared with nonpregnant women. In intrauterine growth restriction the maternal concentrations of most essential amino acids were significantly higher than in appropriate-for-gestational-age pregnancies. This observation, coupled with lower fetal amino acid concentrations in intrauterine growth restriction, leads to significantly lower fetal-maternal differences.CONCLUSIONS: Normal pregnant women have a significant decrease in amino acid concentrations compared with nonpregnant women, whereas in intrauterine growth restriction maternal amino acids are reduced less. Significantly lower fetal-maternal concentration differences are present in intrauterine growth restriction, independent of the degree of severity.