Regulation of the sympathetic nerve discharge bursting pattern during heat stress
Regulation of the sympathetic nerve discharge bursting pattern during heat stress
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DOI：
10.1152/ajpregu.1998.275.6.r1992
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发表时间：
1998-12-01
影响因子：
2.8
通讯作者：
Fels, RJ
中科院分区：
文献类型：
--
作者：
Kenney, MJ;Claassen, DE;Fels, RJ
频域分析用于确定热应激对氯醛糖麻醉大鼠交感神经对以及交感神经和膈神经对之间的放电爆发之间的关系的影响。在核心体温 (T(c)) 从 38 摄氏度升高到 41.4 +/- 0.3 摄氏度期间，记录了肾、内脏、脾和腰神经的交感神经放电 (SND)。进行了以下观察：1) 高温将 SND 的心脏相关爆发模式转变为包含低频、非心脏相关爆发的模式，2) 模式转变在区域选择性中是一致的交感神经，3）热疗增强了 SND 和膈神经爆发之间的频域耦合，4）热疗过程中记录的低频 SND 爆发比心脏相关的爆发包含更多的活动。我们得出的结论是，急性热应激深刻影响负责交感神经活动频率成分的神经回路组织，并且 SND 模式转换为在 T(c) 增加期间增加交感神经活动水平提供了重要策略。
Frequency-domain analyses were used to determine the effect of heat stress on the relationships between the discharge bursts of sympathetic nerve pairs and sympathetic and phrenic nerve pairs in chloralose-anesthetized rats. Sympathetic nerve discharge (SND) was recorded from the renal, splanchnic, splenic, and lumbar nerves during increases in core body temperature (T(c)) from 38 to 41.4 +/- 0.3 degrees C. The following observations were made: 1) hyperthermia transformed the cardiac-related bursting pattern of SND to a pattern that contained low-frequency, non-cardiac-related bursts, 2) the pattern transformation was uniform in regionally selective sympathetic nerves, 3) hyperthermia enhanced the frequency-domain coupling between SND and phrenic nerve bursts, and 4) low-frequency SND bursts recorded during hyperthermia contained significantly more activity than cardiac-related bursts. We conclude that acute heat stress profoundly affects the organization of neural circuits responsible far the frequency components in sympathetic nerve activity and that SND pattern transformation provides an important strategy for increasing the level of activity in sympathetic nerves during increased T(c).