Connectivity-based segmentation of the striatum in Huntington's disease: Vulnerability of motor pathways
Connectivity-based segmentation of the striatum in Huntington's disease: Vulnerability of motor pathways
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DOI：
10.1016/j.nbd.2011.02.010
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发表时间：
2011-06-01
影响因子：
6.1
通讯作者：
Egan, Gary F.
中科院分区：
文献类型：
--
作者：
Bohanna, India;Georgiou-Karistianis, Nellie;Egan, Gary F.
纹状体是亨廷顿病(HD)的主要退行性病变部位，通过具有独特的运动、联想和边缘功能的局部组织回路与大脑皮层相连。目前，还不知道是否所有的皮质-纹状体回路在HD中都受到同样的影响。我们的目的是研究HD患者纹状体内单个皮质-纹状体回路的选择性易损性，并假设运动皮质-纹状体通路将受到最大的影响，这与HD主要是一种运动障碍相一致。应用弥散张量成像(DTI)技术对12例HD患者和14例正常对照的纹状体与7个主要皮质区域的联系进行了研究。根据与大脑皮层的连通性，两组的纹状体都被划分为不同的亚区。测量各亚区的分数各向异性(FA)和平均弥散系数(MD)的体积和DTI显微结构，并进行统计学比较。纤维束造影术显示了对照组和HD患者纹状体皮质连接的地形性组织。在HD患者中，尾状核和壳核的M1和S1亚区的体积、FA和MD与对照组相比差异最大。运动症状与感觉运动纹状体亚区的体积和MD相关，提示感觉运动纹状体变性与运动功能障碍密切相关。弥散张量成像提供了一种新的方法来灵敏地检查HD的回路特异性异常，并发现HD的运动皮质-纹状体回路选择性地脆弱。(C)2011 Elsevier Inc.保留所有权利。
The striatum, the primary site of degeneration in Huntington's disease (HD), connects to the cerebral cortex via topographically organized circuits subserving unique motor, associative and limbic functions. Currently, it is not known whether all cortico-striatal circuits are equally affected in HD. We aimed to study the selective vulnerability of individual cortico-striatal circuits within the striatum in HD, and hypothesized that motor cortico-striatal pathways would be most affected, consistent with HD being a primarily motor disorder. Diffusion Tensor Imaging (DTI) tractography was used to identify connections between the striatum and seven major cortical regions in 12 HD patients and 14 matched controls. The striatum of both groups was parcellated into subregions based on connectivity with the cerebral cortex. Volumetric and DTI microstructural measures of Fractional Anisotropy (FA) and Mean Diffusivity (MD) were obtained within each subregion and compared statistically between groups. Tractography demonstrated the topographic organization of cortical connections in the striatum of both controls and HD patients. In HD patients, the greatest difference from controls in volume, FA and MD was observed in M1 and S1 subregions of the caudate and putamen. Motor symptoms correlated with volume and MD in sensorimotor striatal subregions, suggesting that sensorimotor striatal degeneration is closely related to motor dysfunction. DTI tractography provides a novel approach to sensitively examine circuit-specific abnormalities in HD and has identified that the motor cortico-striatal circuit is selectively vulnerable in HD. (C) 2011 Elsevier Inc. All rights reserved.