Serum levels of MMP-7 in primary brain cancers and brain metastases
Serum levels of MMP-7 in primary brain cancers and brain metastases
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DOI：
10.1080/13102818.2019.1626282
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发表时间：
2019-06-07
影响因子：
1.4
通讯作者：
Vlaykova, Tatyana
中科院分区：
文献类型：
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作者：
Dimitrova, Ivelina;Tacheva, Tanya;Vlaykova, Tatyana
本研究的目的是评估MMP-7血清水平作为脑肿瘤生物标志物的可能作用。这项研究包括50例脑膜瘤，其他良性肿瘤，高级别胶质瘤，脑转移瘤和其他非肿瘤疾病患者和41名对照个体。采用酶联免疫吸附法（ELISA）检测血清MMP-7水平。我们发现，与对照组（1.48 +/- 0.09 ng/mL）相比，良性脑肿瘤（2.33 +/- 0.37 [SEM] ng/mL，p = 0.006）和脑转移瘤（2.54 +/- 0.33 ng/mL，p = 0.0001）患者的MMP-7血清水平显著较高。胶质母细胞瘤（GBM）患者的血清MMP-7水平与对照组相当（1.44 +/- 0.13 ng/mL，p = 0.901），但显著低于良性肿瘤（p = 0.018）和脑转移（p = 0.001）患者。在良性肿瘤患者中，血清MMP-7水平与白细胞计数之间存在正相关性，具有边界显著性（rho = 0.538，p = 0.058）。当比较一些患者（n = 7）在入院时和手术后4-7天获得的血清样品中的MMP-7水平时，没有发现差异（p = 0.448，配对样品t检验）。根据我们的研究结果，MMP-7血清水平可能是良性脑肿瘤和脑转移瘤的有用的血清生物标志物，但不是胶质母细胞瘤。
The aim of this study was to evaluate the possible role of MMP-7 serum levels as biomarkers for brain tumours. This study included 50 patients with meningiomas, other benign tumours, high-grade gliomas, brain metastases and other non-tumour diseases and 41 control individuals. The MMP-7 serum levels were measured by enzyme-linked immunosorbent assay (ELISA). We significantly found higher serum levels of MMP-7 in patients with benign brain tumours (2.33 +/- 0.37 [SEM] ng/mL, p = 0.006) and brain metastases (2.54 +/- 0.33 ng/mL, p = 0.0001) compared to controls (1.48 +/- 0.09 ng/mL). Glioblastoma (GBM) patients had serum MMP-7 levels comparable to those of the controls (1.44 +/- 0.13 ng/mL, p = 0.901) but significantly lower than those of the patients with benign tumours (p = 0.018) and brain metastases (p = 0.001). In patients with benign tumours, there was a positive correlation with borderline significance between serum MMP-7 levels and leukocyte counts (rho = 0.538, p = 0.058). No difference was found (p = 0.448, paired-samples t-test) when comparing the MMP-7 levels in the serum samples obtained at admission and 4-7 days after surgery of some of the patients (n = 7). According to our results, the MMP-7 serum levels might be a useful serum biomarker for benign brain tumours and for brain metastases but not for glioblastoma.