Dosing study of massage for chronic neck pain: protocol for the dose response evaluation and analysis of massage [DREAM] trial.
Dosing study of massage for chronic neck pain: protocol for the dose response evaluation and analysis of massage [DREAM] trial.
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DOI：
10.1186/1472-6882-12-158
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发表时间：
2012-09-18
影响因子：
--
通讯作者：
Cherkin DC
中科院分区：
文献类型：
--
作者：
Sherman KJ;Cook AJ;Kahn JR;Hawkes RJ;Wellman RD;Cherkin DC
尽管按摩越来越受欢迎，但其治疗颈部疼痛的有效性仍不清楚，这主要是由于研究质量较差。先前研究的一个主要缺陷是使用低“剂量”的按摩，按摩治疗师认为这是不够的。不幸的是，每次按摩的分钟数、每周的按摩次数或按摩达到有益或最佳效果所需的治疗周数尚不清楚。本研究旨在通过确定慢性颈部疼痛患者的这些知识差距来弥补我们的知识空白：1）每周治疗次数和个体治疗疗程长度的最佳组合，以及 2）最佳治疗周数。在这项研究中，将从西雅图地区大型医疗保健系统的初级保健诊所招募 228 名患有慢性非特异性颈部疼痛的患者。参与者将被随机分配到等候名单对照组或接受 5 种不同剂量组合之一的 4 周治疗（每周 2 或 3 次 30 分钟治疗，或每周 1、2 或 3 次 60 分钟治疗）。在这个为期 4 周的主要治疗期结束时，最初接受 5 种剂量组合的参与者将被随机分配到第二个治疗期，即不进行额外治疗或每周 6 次 60 分钟的按摩。主要结果，即颈部相关功能障碍和疼痛，将由盲法电话访谈员在随机分组后 5、12 和 26 周进行评估。为了更好地描述治疗效果的轨迹，这些访谈数据将辅以通过网络问卷在 10、16、20 和 39 周收集的结果数据。比较 6 组在主要治疗期间的结果将确定最佳每周剂量，而比较次要治疗期间的结果将确定 10 周的治疗是否优于 4 周。该试验包括广泛的给药方案。如果对任何这些剂量的依从性较差，则将停止这些剂量。该试验已在 ClinicalTrials.gov 注册，ID 号为 NCT01122836
Despite the growing popularity of massage, its effectiveness for treating neck pain remains unclear, largely because of the poor quality of research. A major deficiency of previous studies has been their use of low “doses” of massage that massage therapists consider inadequate. Unfortunately, the number of minutes per massage session, sessions per week, or weeks of treatment necessary for massage to have beneficial or optimal effects are not known. This study is designed to address these gaps in our knowledge by determining, for persons with chronic neck pain: 1) the optimal combination of number of treatments per week and length of individual treatment session, and 2) the optimal number of weeks of treatment. In this study, 228 persons with chronic non-specific neck pain will be recruited from primary health care clinics in a large health care system in the Seattle area. Participants will be randomized to a wait list control group or 4 weeks of treatment with one of 5 different dosing combinations (2 or 3 30-min treatments per week or 1, 2, or 3 60-min treatments per week). At the end of this 4-week primary treatment period, participants initially receiving each of the 5 dosing combinations will be randomized to a secondary treatment period of either no additional treatment or 6 weekly 60-min massages. The primary outcomes, neck-related dysfunction and pain, will be assessed by blinded telephone interviewers 5, 12, and 26 weeks post-randomization. To better characterize the trajectory of treatment effects, these interview data will be supplemented with outcomes data collected by internet questionnaire at 10, 16, 20 and 39 weeks. Comparisons of outcomes for the 6 groups during the primary treatment period will identify the optimal weekly dose, while comparisons of outcomes during the secondary treatment period will determine if 10 weeks of treatment is superior to 4 weeks. A broad dosing schedule was included in this trial. If adherence to any of these doses is poor, those doses will be discontinued. This trial is registered in ClinicalTrials.gov, with the ID number of NCT01122836
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
1.7
作者：
Li, Qian H.
通讯作者：
Li, Qian H.
影响因子：
3
作者：
Coulter, ID;Hurwitz, EL;Shekelle, PG
通讯作者：
Shekelle, PG
影响因子：
7.4
作者：
Borghouts, JAJ;Koes, BW;Bouter, LM
通讯作者：
Bouter, LM
影响因子：
3
作者：
BOVIM, G;SCHRADER, H;SAND, T
通讯作者：
SAND, T