POSSIBLE IMPLICATIONS OF DOXYCYCLINE-RIFAMPIN INTERACTION FOR TREATMENT OF BRUCELLOSIS
POSSIBLE IMPLICATIONS OF DOXYCYCLINE-RIFAMPIN INTERACTION FOR TREATMENT OF BRUCELLOSIS
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DOI：
10.1128/aac.38.12.2798
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发表时间：
1994-12-01
影响因子：
4.9
通讯作者：
VALVERDE, E
中科院分区：
文献类型：
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作者：
COLMENERO, JD;FERNANDEZGALLARDO, LC;VALVERDE, E
我们研究了20例布鲁氏菌病患者随机接受多西环素加链霉素或多西环素加利福平治疗后，利福平和多西环素的相互作用。利福平治疗组的血浆多西环素水平明显低于多西环素和链霉素组。此外，利福平治疗的患者的清除率显著高于多西环素和链霉素治疗的患者，因此消除半衰期和浓度-时间曲线下的面积显著低于多西环素和链霉素组。使用多西环素和链霉素组没有治疗失败或复发，而使用多西环素和利福平治疗的10名患者中有2名治疗失败或复发。血浆多西环素水平与血浆利福平水平呈负相关。在接受利福平治疗的那组患者中，那些乙酰化反应迅速的患者多西环素水平较低。总之，联合利福平治疗可降低多西环素在血浆中的水平。这些数据表明，这种相互作用可能导致治疗失败或复发。
We studied the possible interaction between rifampin and doxycycline in 20 patients with brucellosis treated randomly with either doxycycline and streptomycin or doxycycline and rifampin. The doxycycline levels in the plasma of patients in the group treated,vith rifampin were significantly lower than those in the plasma of patients treated with doxycycline and streptomycin. Furthermore, clearance in patients treated with rifampin was significantly higher than that in patients treated with doxycycline and streptomycin, and consequently, the elimination half-life and the area under the concentration-time curve were significantly lower. There was no therapeutic failure or relapse in the group treated with doxycycline and streptomycin, whereas 2 of 10 patients in the group treated with doxycycline and rifampin had a therapeutic failure or relapse. The plasma doxycycline levels had an inverse correlation with plasma rifampin levels. In the group treated with rifampin, those who were rapid acetylators had lower levels of doxycycline. In conclusion, combined treatment with rifampin reduces the levels of doxycycline in plasma. These data suggest that therapeutic failures or relapses may result from this interaction.