Preoptic hypothalamic warming suppresses laryngeal dilator activity during sleep.
Preoptic hypothalamic warming suppresses laryngeal dilator activity during sleep.
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视前下丘脑变暖抑制睡眠期间喉部扩张器的活动。
DOI：
10.1152/ajpregu.00296.2003
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Szymusiak,Ron
中科院分区：
文献类型：
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作者：
McGinty,Dennis;Metes,Agnes;Alam,MdNoor;Megirian,David;Stewart,Darya;Szymusiak,Ron
在睡眠倾向增强的情况下，例如在睡眠剥夺后，睡眠期间的上气道扩张器活动似乎减少，导致阻塞性睡眠呼吸暂停（OSA）恶化。非快速眼动（NREM）睡眠倾向起源于下丘脑视前区（POA）的睡眠活跃神经元，并通过激活POA温敏神经元（WSNs）来促进。我们假设通过局部POA变暖激活WSNs会抑制环杓后肌（PCA）的活动，PCA是一种气道扩张剂，在NREM睡眠期间。在长期准备无拘无束的猫，PCA表现出吸气爆发在清醒，NREM和REM期间与吸气性脑电活动大致同步。综合吸气PCA活动（IA），峰值活动（PA），并在PCA相对于膈肌吸气活动的开始的前置时间（LT）显着减少在NREM睡眠和进一步减少在REM睡眠与清醒相比。与预热前NREM基线相比，轻度双侧局部POA升温（0.5-1.2°C）显著降低了NREM睡眠期间的IA、PA和LT。在某些动物中，在清醒或REM期间发现POA变暖对PCA活性的影响。由于POA WSN活动在自发NREM睡眠期间增加并调节睡眠倾向，我们假设这种激活有助于减少OSA患者的气道扩张剂活动。
Upper airway dilator activity during sleep appears to be diminished under conditions of enhanced sleep propensity, such as after sleep deprivation, leading to worsening of obstructive sleep apnea (OSA). Non-rapid eye movement (NREM) sleep propensity originates in sleep-active neurons of the preoptic area (POA) of the hypothalamus and is facilitated by activation of POA warm-sensitive neurons (WSNs). We hypothesized that activation of WSNs by local POA warming would inhibit activity of the posterior cricoarytenoid (PCA) muscle, an airway dilator, during NREM sleep. In chronically prepared unrestrained cats, the PCA exhibited inspiratory bursts in approximate synchrony with inspiratory diaphragmatic activity during waking, NREM, and REM. Integrated inspiratory PCA activity (IA), peak activity (PA), and the lead time (LT) of the onset of inspiratory activity in PCA relative to diaphragm were significantly reduced in NREM sleep and further reduced during REM sleep compared with waking. Mild bilateral local POA warming (0.5–1.2°C) significantly reduced IA, PA, and LT during NREM sleep compared with a prewarming NREM baseline. In some animals, effects of POA warming on PCA activity were found during waking or REM. Because POA WSN activity is increased during spontaneous NREM sleep and regulates sleep propensity, we hypothesize that this activation contributes to reduction of airway dilator activity in patients with OSA.