Reproductive consequences of developmental phytoestrogen exposure.
Reproductive consequences of developmental phytoestrogen exposure.
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发育性植物雌激素暴露的生殖后果。
DOI：
10.1530/rep-11-0369
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Williams CJ
中科院分区：
文献类型：
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作者：
Jefferson WN;Patisaul HB;Williams CJ
植物雌激素是来源于植物的雌激素类化合物，广泛存在于人类和动物的饮食中。这些化学物质通常比雌二醇效力低得多，但通过类似的机制起作用。人类接触植物雌激素的最常见来源是富含大豆黄酮、染料木素和大豆黄酮的大豆衍生食品。在以大豆为基础的婴儿配方奶粉中也发现了相对较高水平的这些维生素E酮。植物雌激素已被推广为合成雌激素的健康替代品，并在许多膳食补充剂中发现。本综述的目的是研究植物雌激素暴露的证据，特别是在生命的发育敏感期，对未来的生殖健康的后果。
Phytoestrogens, estrogenic compounds derived from plants, are ubiquitous in human and animal diets. These chemicals are generally much less potent than estradiol but act via similar mechanisms. The most common source of phytoestrogen exposure to humans is soybean-derived foods that are rich in the isoflavones genistein and daidzein. These isoflavones are also found at relatively high levels in soy-based infant formulas. Phytoestrogens have been promoted as healthy alternatives to synthetic estrogens and are found in many dietary supplements. The aim of this review is to examine the evidence that phytoestrogen exposure, particularly in developmentally sensitive periods of life, has consequences for future reproductive health.