Cohort Profile Cohort Profile : The Malaysian Cohort ( TMC ) project : a prospective study of non-communicable diseases in a multi-ethnic population
Cohort Profile Cohort Profile : The Malaysian Cohort ( TMC ) project : a prospective study of non-communicable diseases in a multi-ethnic population
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队列简介 队列简介：马来西亚队列 (TMC) 项目：多种族人群非传染性疾病的前瞻性研究
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
N. Mahadi
中科院分区：
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作者：
R. Jamal;Syed Zulkifli Syed Zakaria;Mohd Arman;Kamaruddin;N. Jalal;N. Ismail;Norkhamiwati Mohd;Kamil;N. Abdullah;N. Baharudin;Noor;H. Hussin;H. Othman;N. Mahadi
马来西亚队列研究是由马来西亚政府于2005年发起的。这项以人口为基础的队列研究采用自上而下的方法，确保为旨在招募10万名35-70岁的人的项目分配足够的资金。参与者来自农村和城市地区以及各种社会经济群体。该研究的主要目的是确定风险因素，研究基因-环境相互作用，并发现早期发现癌症和其他疾病的生物标志物。在招募时，进行了一次基于尸检的访谈，进行了生物物理测量，并收集、处理和储存了生物标本。基线检查包括空腹血糖、空腹血脂、肾功能和全血细胞计数。从2006年4月到2012年9月底，我们共招募了106527名参与者。基线患病率数据显示，16.6%的参与者患有糖尿病，46.5%患有高血压，44.9%患有高胆固醇血症，17.7%患有肥胖症。后续阶段于2013年6月开始。这是马来西亚最全面和最大的队列研究，已成为流行病学和生物学研究的宝贵资源。有关合作和数据访问的信息，研究人员可以联系项目负责人（rahmanj@ppukm.ukm.edu.my）。VC作者2014由牛津大学出版社代表国际流行病学协会出版423这是一篇开放获取的文章，根据知识共享署名非商业许可证（http：//creativecommons.org/licenses/by-nc/3.0/）的条款分发，该许可证允许在任何媒体上进行非商业性的再使用，分发和复制，前提是正确引用原始作品。对于商业重复使用，请联系journals. oup.com International Journal of Epidemiology，2015，423-431 doi：10.1093/ije/dyu 089 Advance Access Publication Date：11 April 2014
The Malaysian Cohort study was initiated in 2005 by the Malaysian government. The topdown approach to this population-based cohort study ensured the allocation of sufficient funding for the project which aimed to recruit 100 000 individuals aged 35–70 years. Participants were recruited from rural and urban areas as well as from various socioeconomic groups. The main objectives of the study were to identify risk factors, to study gene-environment interaction and to discover biomarkers for the early detection of cancers and other diseases. At recruitment, a questionnaire-based interview was conducted, biophysical measurements were performed and biospecimens were collected, processed and stored. Baseline investigations included fasting blood sugar, fasting lipid profile, renal profile and full blood count. From April 2006 to the end of September 2012 we recruited a total of 106 527participants. The baseline prevalence data showed 16.6% participants with diabetes, 46.5% with hypertension, 44.9% with hypercholesterolaemia and 17.7% with obesity. The follow-up phase commenced in June 2013. This is the most comprehensive and biggest cohort study in Malaysia, and has become a valuable resource for epidemiological and biological research. For information on collaboration and also data access, investigators can contact the project leader at (rahmanj@ppukm.ukm.edu.my). VC The Author 2014. Published by Oxford University Press on behalf of the International Epidemiological Association 423 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com International Journal of Epidemiology, 2015, 423–431 doi: 10.1093/ije/dyu089 Advance Access Publication Date: 11 April 2014