Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors
Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors
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DOI：
10.1523/jneurosci.1309-08.2008
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发表时间：
2008-05-28
影响因子：
5.3
通讯作者：
Rangel, Antonio
中科院分区：
文献类型：
--
作者：
Hare, Todd A.;O'Doherty, John;Rangel, Antonio
为了做出合理的经济决策，大脑需要计算几个不同的价值相关信号。这些包括目标值，用于衡量由所考虑的每个行动产生的结果产生的预测奖励，决策值，用于衡量采取不同行动的净价值，以及预测误差，用于衡量与个人先前奖励期望的偏差。我们使用功能性磁共振成像和一种新的决策范式来分离这三种计算的神经基础。我们的研究结果表明，他们是由不同的神经基板：目标值与活动在内侧眶额皮质，决策值与活动在中央眶额皮质，预测误差与活动在腹侧纹状体。
To make sound economic decisions, the brain needs to compute several different value-related signals. These include goal values that measure the predicted reward that results from the outcome generated by each of the actions under consideration, decision values that measure the net value of taking the different actions, and prediction errors that measure deviations from individuals' previous reward expectations. We used functional magnetic resonance imaging and a novel decision-making paradigm to dissociate the neural basis of these three computations. Our results show that they are supported by different neural substrates: goal values are correlated with activity in the medial orbitofrontal cortex, decision values are correlated with activity in the central orbitofrontal cortex, and prediction errors are correlated with activity in the ventral striatum.