Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study.
Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study.
复制标题
神经氨酸酶抑制剂化学预防中的作用在控制医院流感：一项观察性研究。
DOI：
10.1111/j.1750-2659.2011.00311.x
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发表时间：
2012-07
影响因子：
4.4
通讯作者：
Fujita J
中科院分区：
文献类型：
--
作者：
Higa F;Tateyama M;Tomishima M;Mukatake S;Yamashiro T;Owan T;Haranaga S;Fujita J
请引用本文作为：Higa et al.（2012）神经氨酸酶抑制剂化学预防在控制医院内流感中的作用：一项观察性研究。流感和其他呼吸道病毒6（4），299-303。 背景流感爆发可能导致急诊医院服务中断。 目的在这项研究中，我们回顾性评价了神经氨酸酶抑制剂预防流感医院内传播的应用。 患者/方法在3年的研究期间，确定了202例流感指示病例[30例住院患者和172名医护人员（HCW）]和762名与指示病例有密切接触的个体（248例住院患者和514名HCW）。 在这些接触者中，416人接受了神经氨酸酶抑制剂化学预防。 结果当指示病例和密切接触者均为住院患者时，密切接触者中接受过药物预防治疗者的流感发病率低于未接受药物预防治疗者（比值比，0.07;可信区间，0.01 ~ 0.49; P = 0.012）。 相反，当指示病例为HCW时，密切接触者接受或未接受化学预防的流感发病率没有差异。 结论本研究提示，化学预防可能有助于预防住院患者之间的医院感染传播。
Please cite this paper as: Higa et al. (2012) Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study. Influenza and Other Respiratory Viruses 6(4), 299–303. Background An influenza outbreak might result in disruption of services at acute care setting hospitals. Objectives In this study, we retrospectively evaluated the use of neuraminidase inhibitor chemoprophylaxis for prevention of nosocomial spread of influenza in a university hospital. Patients/Methods During the 3‐year study period, 202 index cases of influenza [30 hospitalized patients and 172 healthcare workers (HCW)] and 762 individuals who had had close contact with the index cases (248 hospitalized patients and 514 HCW) were identified. Of these contacts, 416 received neuraminidase inhibitor chemoprophylaxis. Results When both the index cases and the close contacts were hospitalized patients, the incidence of influenza was lower among the close contacts who received chemoprophylaxis than among those who did not (odds ratio, 0·07; confidence interval, 0·01–0·49; P = 0·012). In contrast, when the index cases were HCW, the incidence of influenza was not different between close contacts who did or did not receive chemoprophylaxis. Conclusions This study suggests that chemoprophylaxis might be useful to prevent nosocomial spread of infection between hospitalized patients.
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影响因子：
168.9
作者：
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通讯作者：
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影响因子：
158.5
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DOI：
10.1046/j.1532-5415.2001.49204.x
发表时间：
2001-08-01
影响因子：
6.3
作者：
Peters, PH;Gravenstein, S;Ward, P
通讯作者：
Ward, P