Expression of transforming growth factor-α and epidermal growth factor receptor in gastrointestinal stromal tumours
Expression of transforming growth factor-α and epidermal growth factor receptor in gastrointestinal stromal tumours
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DOI：
10.1007/s004280050407
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发表时间：
1999-08-01
期刊：
影响因子：
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通讯作者：
Banner, B
中科院分区：
文献类型：
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作者：
Cai, YC;Jiang, Z;Banner, B
表皮生长因子受体（EGFR）的激活与细胞生长和转化有关。转化生长因子-α（TGF-α）和表皮生长因子均结合并激活EGFR。我们研究了TGF-α和两种EGFR（HER-1和HER-2）的表达在胃（n=9）和小肠（n=6）的胃肠道间质瘤（GIST），使用标准的免疫染色技术在石蜡包埋切片。大多数GIST表达TGF-α，少数表达HER-1。所有HER-1阳性肿瘤均表达TGF-α。这些结果表明，TGF-α/EGFR自分泌环存在于GIST中，并且TGF-α通过其与HER-1的相互作用促进GIST肿瘤细胞的增殖。这是GIST中自分泌回路的首次描述。相反，HER-2在任何GIST中都不表达。
Activation of epidermal growth factor receptor (EGFR) is associated with cell growth and transformation. Both transforming growth factor-alpha (TGF-alpha) and epidermal growth factor bind to and activate EGFR. We studied the expression of TGF-alpha and two EGFRs (HER-1 and HER-2) in gastrointestinal stromal tumours (GISTs) of the stomach (n=9) and small intestine (n=6) using standard immunostaining techniques in paraffin-embedded sections. Most GISTs expressed TGF-alpha, and a few expressed HER-1. All HER-1-positive tumours expressed TGF-alpha. These results suggest that a TGF-alpha/EGFR autocrine loop is present in GIST and that TGF-alpha promotes proliferation of GIST tumour cells through its interaction with HER-1 in at least some GISTs. This is the first description of an autocrine loop in GIST. In contrast, HER-2 is not expressed in any GIST.