Effect of azithromycin on murine arteriosclerosis exacerbated by Chlamydia pneumoniae.
Effect of azithromycin on murine arteriosclerosis exacerbated by Chlamydia pneumoniae.
复制标题
阿奇霉素对肺炎衣原体加剧的小鼠动脉硬化的作用。
DOI：
10.1086/317941
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Lowenstein,CJ
中科院分区：
文献类型：
--
作者：
Rothstein,NM;Quinn,TC;Madico,G;Gaydos,CA;Lowenstein,CJ
Chlamydia pneumoniaeinfection can exacerbate atherosclerosis in animals. To test the hypothesis that antibiotic therapy inhibits the atherogenic effects ofC. pneumoniaeinfection, 10-week-old apolipoprotein E (ApoE) null mice were infected withC. pneumoniaeor placebo, were treated for 2 weeks after infection with azithromycin or placebo, and were killed at 20 weeks of age. Infection did not affect the size of the aortic lesion, and antibiotic treatment had no effect. Another group of mice, 12-week-old ApoE mice, were infected withC. pneumoniaeor placebo, were treated for 2 weeks after infection with azithromycin or placebo, and were killed at 26 weeks of age.C. pneumoniaeinfection increased the size of the lesion in infected mice, but azithromycin did not reduce the size of the aortic lesion in infected mice. Therefore, immediate therapy of acute infection may be necessary to prevent the proatherogenic effects ofC. pneumoniaeinfection.
