High-transport membrane is a risk factor for encapsulating peritoneal sclerosis developing after long-term continuous ambulatory peritoneal dialysis treatment.
High-transport membrane is a risk factor for encapsulating peritoneal sclerosis developing after long-term continuous ambulatory peritoneal dialysis treatment.
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高转运膜是长期连续不卧床腹膜透析治疗后发生包裹性腹膜硬化的危险因素。
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Tastuo Hosoya
中科院分区：
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作者：
R. Yamamoto;M. Nakayama;T. Hasegawa;Numata Miwako;Hiroyasu Yamamoto;Keitaro Yokoyami;Masato Ikeda;N. Kato;H. Hayakawa;Hajime Takahashi;Yasushi Otsuka;Y. Kawaguchi;Tastuo Hosoya
腹膜功能增强被认为是发生包裹性腹膜硬化（EPS）的危险因素;然而，临床证据很少。本研究旨在阐明腹膜透析（PD）退出后发生EPS的患者腹膜功能的特殊性。我们研究了12例在PD停药后发生EPS的患者[（EPS组）平均PD持续时间：109个月; EPS发生的平均时间：停药后7.0个月]和128例未发生EPS的患者（非EPS组）。所有140例患者均退出持续性非卧床腹膜透析（CAPD），并观察24个月。根据每年的腹膜平衡试验（PET）记录，我们分析了（1）患者在PD时不同持续时间的透析液与血浆（D/P）肌酐比值，以及（2）腹膜高转运（HT）状态的累积出现率。在PD病程的第6 ~ 10年，EPS组的D/P肌酐均值显著高于非EPS组。EPS组HT的累积发生率明显高于非EPS组，提示EPS组HT膜的形成较早。在PD停药后发生EPS的患者中，在PD治疗的某些时期观察到早期D/P肌酐升高（归类为HT状态）。这一发现可能表明，腹膜的HT状态是EPS的早期标志物，PET可用于检测EPS高危患者。
Increased peritoneal function has been suggested to be a risk factor for developing encapsulating peritoneal sclerosis (EPS); however, clinical evidence is scarce. The present study aimed to clarify the specific character of peritoneal function in patients who developed EPS after withdrawal from peritoneal dialysis (PD). We studied 12 patients who developed EPS after PD withdrawal [(EPS group) mean PD duration: 109 months; mean period of EPS development: 7.0 months after withdrawal] and 128 patients who did not develop EPS (non EPS group). All 140 patients were withdrawn from continuous ambulatory peritoneal dialysis (CAPD) and were observed for the following 24 months. Based on the records of the annual peritoneal equilibration tests (PETs), we analyzed (1) the patients' dialysate-to-plasma (D/P) creatinine at various durations on PD, and (2) the accumulative appearance incidence of high-transport (HT) state of peritoneal membrane. The mean D/P creatinine in EPS group was significantly higher than that in the non EPS group in the course of PD from the 6th to the 10th year. The accumulative incidence of HT was significantly higher in the EPS group than in the non EPS group, indicating early development of HT membrane in EPS group. Early development of increased D/P creatinine, classified as HT state, was observed during certain periods on PD in patients who developed EPS after PD withdrawal. That finding may indicate that HT state of peritoneal membrane is an early marker for EPS, and that the PET is useful to detect patients at high risk of EPS.