Use of biological markers to validate self-reported dietary intake in a random sample of the European Prospective Investigation into Cancer United Kingdom Norfolk cohort.
Use of biological markers to validate self-reported dietary intake in a random sample of the European Prospective Investigation into Cancer United Kingdom Norfolk cohort.
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DOI：
10.1093/ajcn/74.2.188
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发表时间：
2001-08
期刊：
影响因子：
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通讯作者：
N. McKeown;N. Day;A. Welch;S. Runswick;R. Luben;A. Mulligan;A. McTaggart;S. Bingham
中科院分区：
文献类型：
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作者：
N. McKeown;N. Day;A. Welch;S. Runswick;R. Luben;A. Mulligan;A. McTaggart;S. Bingham
背景：饮食评估方法的有效性应该在饮食与疾病相关性报告之前建立。目的：我们的目标是验证7天食物日记和食物频率问卷（FFQ）对尿（氮，钾和钠）和血液（血浆抗坏血酸）中摄入量的独立生物标志物。设计：从欧洲癌症前瞻性研究英国诺福克队列（一个约25000人的自由生活队列）中招募了146名健康中年男性和女性。在9个月的时间内，尿氮，钾，钠估计从2 - 6个完整的24小时尿液收集134例受试者和血浆抗坏血酸估计从2 - 3个空腹血液样本118例。受试者完成2个FFQ和2个7天食物日记。结果在男性和女性中，24 h尿氮排泄量与7 d饮食日记中的饮食摄入量之间的相关性（r = 0.57 - 0.67）高于FFQ（r = 0.21 - 0.29）。同样，7天饮食日记（r = 0.51 - 0.55）的尿钾和膳食钾之间的相关性高于FFQ（r = 0.32 - 0.34）。7天食物日记（r = 0.40 - 0.52）和FFQ（r = 0.44 - 0.45）之间血浆抗坏血酸和膳食维生素C之间的相关性没有总体差异。结论这些数据表明，尽管受试者负担增加，但7天食物日记比FFQ更好地估计了该研究人群的氮和钾摄入量。然而，对于血浆抗坏血酸，FFQ和7天食物日记提供了一个类似的排名的主题根据维生素C的摄入量。
BACKGROUND The validity of dietary assessment methods should be established before diet-disease associations are reported. OBJECTIVE Our objective was to validate a 7-d food diary and a food-frequency questionnaire (FFQ) against independent biomarkers of intake in urine (nitrogen, potassium, and sodium) and blood (plasma ascorbic acid). DESIGN A total of 146 healthy middle-aged men and women were recruited from the European Prospective Investigation into Cancer UK Norfolk cohort, a free-living cohort of approximately 25000 persons. Over a 9-mo period, urinary nitrogen, potassium, and sodium were estimated from 2-6 complete 24-h urine collections in 134 subjects and plasma ascorbic acid was estimated from 2-3 fasting blood samples in 118 subjects. Subjects completed 2 FFQs and two 7-d food diaries. RESULTS In men and women combined, correlations between 24-h urinary nitrogen excretion and dietary intake from the 7-d food diary were high (r = 0.57-0.67) compared with those for the FFQ (r = 0.21-0.29). Similarly, correlations between urinary potassium and dietary potassium were higher for the 7-d food diary (r = 0.51-0.55) than for the FFQ (r = 0.32-0.34). There was no overall difference in correlations between plasma ascorbic acid and dietary vitamin C between the 7-d food diary (r = 0.40-0.52) and the FFQ (r = 0.44-0.45). CONCLUSIONS These data indicate that, despite increased subject burden, the 7-d food diary provided a better estimate of nitrogen and potassium intakes than did the FFQ in this study population. However, with respect to plasma ascorbic acid, both the FFQ and 7-d food diary provided a similar ranking of subjects according to vitamin C intake.