Evaluation of the immunoglobulin G avidity test for diagnosis of toxoplasmic lymphadenopathy
Evaluation of the immunoglobulin G avidity test for diagnosis of toxoplasmic lymphadenopathy
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DOI：
10.1128/jcm.42.10.4627-4631.2004
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发表时间：
2004-10-01
影响因子：
9.4
通讯作者：
Remington, JS
中科院分区：
文献类型：
--
作者：
Montoya, JG;Huffman, HB;Remington, JS
弓形虫淋巴结病（TL）是急性获得性弓形虫感染在正常人中最常见的临床表现。诊断通过血清学方法和淋巴结活检确定。最近，弓形虫免疫球蛋白G（IgG）抗体的亲合力测试已被引入，以帮助区分最近获得的寄生虫感染和远处感染。我们研究了亲合力测试，以确定该方法的有用性，并确定TL中IgG亲合力的演变。研究了73例连续诊断为TL的患者。从淋巴结病临床发作开始，IgG亲合力试验滴度具有时间依赖性。低IgG抗体亲合力试验结果观察到的患者谁发展淋巴结病，
Toxoplasmic lymphadenopathy (TL) is the most common clinical manifestation of acute acquired toxoplasma infection in normal individuals. The diagnosis is established by serologic methods and lymph node biopsy. Recently, tests for avidity of toxoplasma immunoglobulin G (IgG) antibodies have been introduced to help discriminate between recently acquired and distant infection with the parasite. We studied an avidity test to define the usefulness of this method and to determine the evolution of the IgG avidity in TL. Seventy-three consecutive patients diagnosed as having TL were studied. IgG avidity test titers were noted to be time dependent from the clinical onset of lymphadenopathy. Low IgG avidity test results were observed in patients who had developed lymphadenopathy from