TRANSCRIPTIONAL ACTIVATION OF A RAS-LIKE GENE (KIR) BY ONCOGENIC TYROSINE KINASES
TRANSCRIPTIONAL ACTIVATION OF A RAS-LIKE GENE (KIR) BY ONCOGENIC TYROSINE KINASES
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DOI：
10.1073/pnas.91.26.12448
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发表时间：
1994-12-20
影响因子：
11.1
通讯作者：
WITTE, O
中科院分区：
文献类型：
--
作者：
COHEN, L;MOHR, R;WITTE, O
We report the characterization of a member of the ras gene family that is overexpressed in cells transformed by abl tyrosine kinase oncogenes. The gene, named kir (for kinase-inducible ras-like), is induced at the transcriptional level, kit mRNA has a rapid turnover and encodes a protein of 33 kDa with guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. kir was cloned by differential screening of genes present in fully malignant versus growth factor-independent cell lines expressing wild-type or mutant forms of BCR/ABL, BCR/ABL and v-Abl induce transcription of the kir gene via specific signaling pathway(s), but kir overexpression alone is not sufficient to mediate transformation.
