The Epidemiology of Human Telomeres: Faults and Promises
The Epidemiology of Human Telomeres: Faults and Promises
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DOI：
10.1093/gerona/63.9.979
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发表时间：
2008-09-01
影响因子：
5.1
通讯作者：
Aviv, Abraham
中科院分区：
文献类型：
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作者：
Aviv, Abraham
端粒生物学的流行病学领域存在着被忽视但日益严重的问题。该领域的重点一直是白细胞端粒动力学，表面上登记氧化应激和炎症的累积负担，重要的是，研究白细胞端粒长度和衰老指标和衰老疾病之间的关联还包括许多受流行病学和实验室方法学影响的研究。这些研究的缺点混淆了发现，破坏了结论，并损害了该领域实现其目标的能力，其中包括更好地了解人类衰老。并提出了解决这些问题的具体措施。其中包括呼吁公正评价目前用于测量端粒参数的两种主要方法（Southern印迹和定量聚合酶链反应），以及提出一个工作模型来测试白细胞端粒动力学与人类衰老和寿命的潜在联系。
There are neglected but growing problems in the epidemiological field of telomere biology. The focus of the field has been on leukocyte telomere dynamics, which ostensibly register the accruing burden of oxidative stress and inflammation, Important as they are, studies that have examined associations between leukocyte telomere length and indices of aging and diseases of aging also include many that are compromised by poor epidemiological and laboratory methodology. The shortcomings of these studies muddle findings, undermine conclusions, and compromise the ability of the field to attain its goals, which include a better understanding of human aging. Specific steps are delineated to resolve these problems. They include a call for an impartial evaluation of the two major methods (Southern blots and quantitative polymerase chain reaction) currently in use to measure telomere parameters and a proposal for a working model to test the potential connections of leukocyte telomere dynamics with human aging and longevity.