Use of T1-weighted/T2-weighted magnetic resonance ratio images to elucidate changes in the schizophrenic brain.
Use of T1-weighted/T2-weighted magnetic resonance ratio images to elucidate changes in the schizophrenic brain.
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DOI：
10.1002/brb3.399
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发表时间：
2015-10
影响因子：
3.1
通讯作者：
Kaneoke Y
中科院分区：
文献类型：
--
作者：
Iwatani J;Ishida T;Donishi T;Ukai S;Shinosaki K;Terada M;Kaneoke Y
一个主要假设表明，精神分裂症 (SZ) 是一种神经发育障碍，由遗传缺陷引起，并与影响突触和髓磷脂形成的环境风险因素相关。最近对 SZ 脑的磁共振成像 (MRI) 研究表明，灰质 (GM) 减少，白质 (WM) 各向异性分数减少。在本研究中，我们使用 T1 加权 (T1w)/T2 加权 (T2w) MRI 比率图像，这增加了髓磷脂相关的信号对比度并减少了接收器线圈偏差。我们测量了 29 名 SZ 患者和 33 名健康对照 (HC) 的 T1w/T2w 比率图像信号强度，然后将其与偏差校正的 T1w 图像进行比较。所有 SZ GM 和 WM 体素的平均 T1w/T2w 比率信号强度值均显着低于 HC 值（以年龄、性别、惯用手和病前智商作为讨厌协变量的协方差分析）。 SZ 平均 WM T1w/T2w 比值与总体功能评估 (GAF) 评分相关，并且与阳性和阴性综合征量表的阳性精神病症状呈负相关。基于体素的分析显示，SZ GM 右腹壳核中的 T1w/T2w 比图像信号强度值显着降低。 SZ 组和 HC 组之间的 T1w 图像强度没有差异。 T1 加权/T2 加权比率成像增加了 SZ 病理变化的可检测性。 SZ 脑信号强度降低可能是由于髓磷脂含量减少所致；因此，使用 T1w/T2w 比率图像绘制与髓磷脂相关的 SZ 脑变化可能有助于研究 SZ 脑异常。
One leading hypothesis suggests that schizophrenia (SZ) is a neurodevelopmental disorder caused by genetic defects in association with environmental risk factors that affect synapse and myelin formation. Recent magnetic resonance imaging (MRI) studies of SZ brain showed both gray matter (GM) reduction and white matter (WM) fractional anisotropy reduction. In this study, we used T1‐weighted (T1w)/T2‐weighted (T2w) MRI ratio images, which increase myelin‐related signal contrast and reduce receiver‐coil bias. We measured T1w/T2w ratio image signal intensity in 29 patients with SZ and 33 healthy controls (HCs), and then compared them against bias‐corrected T1w images. Mean T1w/T2w ratio signal intensity values across all SZ GM and WM voxels were significantly lower than those for the HC values (analysis of covariance with age, gender, handedness, and premorbid intelligence quotient as nuisance covariates). SZ mean WM T1w/T2w ratio values were related to Global Assessment of Functioning (GAF) scores and were inversely related to the positive psychotic symptoms of the Positive and Negative Syndrome Scale. Voxel‐based analysis revealed significantly lower T1w/T2w ratio image signal intensity values in the right ventral putamen in SZ GM. T1w image intensities did not differ between the SZ and HC groups. T1‐weighted/T2‐weighted ratio imaging increased the detectability of SZ pathological changes. Reduced SZ brain signal intensity is likely due to diminished myelin content; therefore, mapping myelin‐related SZ brain changes using T1w/T2w ratio images may be useful for studies of SZ brain abnormalities.