Acinetobacter infections prevalence and frequency of the antibiotics resistance: comparative study of intensive care units versus other hospital units.
Acinetobacter infections prevalence and frequency of the antibiotics resistance: comparative study of intensive care units versus other hospital units.
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DOI：
10.11604/pamj.2016.23.191.7915
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Elouennass M
中科院分区：
文献类型：
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作者：
Uwingabiye J;Frikh M;Lemnouer A;Bssaibis F;Belefquih B;Maleb A;Dahraoui S;Belyamani L;Bait A;Haimeur C;Louzi L;Ibrahimi A;Elouennass M
本研究旨在通过比较拉巴特穆罕默德五世军事教学医院重症监护病房（icu）与其他病房的结果，确定不动杆菌sp临床分离频率及其抗生素敏感性模式。这是一项为期2年的回顾性研究，我们收集了2012年至2014年住院患者感染诊断样本中获得的所有临床分离不动杆菌sp。在研究期间，收集到临床和非重复分离的不动杆菌441株，占临床分离细菌总数的6.94% (n = 6352)，占革兰氏阴性棒菌总数的9.6% （n = 4569）。其中男性191例（65.2%），性别比1.9，中位年龄56岁（四分位数间距42 ~ 68岁）。临床分离的不动杆菌主要来自呼吸道（44.67%），其次是血液培养（14.51%）。对环丙沙星、头孢他啶、哌拉西林/他唑巴坦、亚胺培南、阿米卡星、妥布霉素、奈替米星、利福平、粘菌素的耐药率分别为87%、86%、79%、76%；52% 43% 33% 32%和1.7%除粘菌素、四环素、利福平外，icu与其他单位耐药差异均有统计学意义（p <0.05）。本文表明，解决多重耐药不动杆菌感染的流行和高发问题，需要控制医院环境，优化医院的手卫生和抗生素使用。
This study aims to determine the Acinetobacter sp clinical isolates frequency and its antibiotic susceptibility pattern by comparing results obtained from the Intensive Care Units (ICUs) to that of other units at the Mohammed V Military Teaching Hospital in Rabat. This is a retrospective study over a 2-years period where we collected all clinical isolates of Acinetobacter sp obtained from samples for infection diagnosis performed on hospitalized patients between 2012 to 2014. During the study period, 441 clinical and non-repetitive isolates of Acinetobacter sp were collected representing 6.94% of all bacterial clinical isolates (n = 6352) and 9.6% of Gram negative rods (n = 4569). More than a half of the isolates were from the ICUs and were obtained from 293 infected patients of which 65, 2% (191 cases) were males (sex ratio = 1.9) and the median age was 56 years (interquartile range: 42-68 years). Acinetobacter clinical isolates were obtained from respiratory samples (44.67%) followed by blood cultures (14.51%). The resistance to ciprofloxacin, ceftazidime, piperacillin / tazobactam, imipenem, amikacin, tobramycin, netilmicin, rifampicin and colistin was respectively 87%, 86%, 79%, 76%; 52%, 43%, 33% 32% and 1.7%. The difference in resistance between the ICUs and the other units was statistically significant (p <0.05) except for colistin, tetracycline and rifampicin. This paper shows that solving the problem of prevalence and high rate of multidrug resistant Acinetobacter infection which represents a therapeutic impasse, requires the control of the hospital environment and optimizing hands hygiene and antibiotics use in the hospital.