Molecular forms of natriuretic peptides in heart failure and their implications.
Molecular forms of natriuretic peptides in heart failure and their implications.
复制标题
DOI：
10.1136/hrt.2008.164145
复制
发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Wu Q
中科院分区：
文献类型：
--
作者：
Xu-Cai YO;Wu Q
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are important biomarkers in the diagnosis and risk stratification for heart failure (HF). These peptides are synthesized as inactive precursors, pro-ANP and pro-BNP, which are converted to biologically active 28-amino-acid ANP and 32-amino-acid BNP, respectively. Most immunoassays currently used in the clinical setting, however, do not determine precise molecular forms of these natriuretic peptides, which may vary depending on the pathophysiological state of HF. Analysis from chromatography-based studies reveals that in HF, inactive pro-ANP and pro-BNP forms often predominate. This indicates that the bioactive forms of natriuretic peptides may not be processed proportionally in patients with advanced HF. Distinguishing the bioactive natriuretic peptides from their inactive forms in plasma may help to define the role of these peptides in the pathogenesis of HF and provide new insights into the treatment of the disease.
登录
查看更多内容
影响因子：
9.3
作者：
Giuliani, Isabelle;Rieunier, Francois;Villard, Sylvie
通讯作者：
Villard, Sylvie
影响因子：
5.8
作者：
ANDO, K;HIRATA, Y;MARUMO, F
通讯作者：
MARUMO, F
影响因子：
56.9
作者：
CHIMOSKEY, JE;SPIELMAN, WS;HEIDEMANN, SR
通讯作者：
HEIDEMANN, SR
DOI：
10.1073/pnas.0508782102
发表时间：
2005-11-29
影响因子：
11.1
作者：
Hawkridge, AM;Heublein, DM;Muddiman, DC
通讯作者：
Muddiman, DC
影响因子：
4
作者：
Azizi, C;Maistre, G;Carayon, A
通讯作者：
Carayon, A