Developmental programming and hypertension.
Developmental programming and hypertension.
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DOI：
10.1097/mnh.0b013e328326092c
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发表时间：
2009-03
影响因子：
3.2
通讯作者：
Alexander BT
中科院分区：
文献类型：
--
作者：
Nuyt AM;Alexander BT
越来越多的证据表明，生命早期的不良事件或接触与成年发病疾病有关。在世界许多地方进行了重要的流行病学研究之后，现在的研究重点是器官功能障碍的机制，以及对不良围产期状况的共同因素（如营养、氧化剂和毒素暴露）之间相互作用的理解。这篇综述将集中在我们对高血压发育规划的理解方面的进展。最近的研究揭示了肾少血症和肾功能受损、血管功能和结构改变以及心血管系统的交感调节的重要机制。此外，产前侮辱和产后条件之间的相互作用是深入研究的主题。早产与宫内生长限制对高血压的调节不同。随着产前暴露于糖皮质激素和营养不平衡，围产期氧化应激的关键作用正在出现。虽然人们越来越认识到产前和产后对成人血压的影响之间相互作用的复杂性，但产后生活在（积极）调节发育规划方面的重要性，为逆转规划和预防或减少相关的成人发病疾病提供了一个关键的机会窗口。
There is a growing body of evidence linking adverse events or exposures during early life and adult-onset diseases. After important epidemiological studies from many parts of the world, research now focuses on mechanisms of organ dysfunction and on refining the understanding of the interaction between common elements of adverse perinatal conditions, such as nutrition, oxidants, and toxins exposures. This review will focus on advances in our comprehension of developmental programming of hypertension. Recent studies have unraveled important mechanisms of oligonephronia and impaired renal function, altered vascular function and structure as well as sympathetic regulation of the cardiovascular system. Furthermore, interactions between prenatal insults and postnatal conditions are the subject of intensive research. Prematurity vs. intrauterine growth restriction modulate differently programming of high blood pressure. Along with antenatal exposure to glucocorticoids and imbalanced nutrition, a critical role for perinatal oxidative stress is emerging. While the complexity of the interactions between antenatal and postnatal influences on adult blood pressure is increasingly recognized, the importance of postnatal life in (positively) modulating developmental programming offers the hope of a critical window of opportunity to reverse programming and prevent or reduce related adult-onset diseases.