Chlamydia pneumoniae strain TWAR antibody and angiographically demonstrated coronary artery disease.
Chlamydia pneumoniae strain TWAR antibody and angiographically demonstrated coronary artery disease.
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肺炎衣原体菌株 TWAR 抗体和血管造影显示冠状动脉疾病。
DOI：
10.1161/01.atv.11.3.547
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Weiss,NS
中科院分区：
文献类型：
--
作者：
Thom,DH;Wang,SP;Grayston,JT;Siscovick,DS;Stewart,DK;Kronmal,RA;Weiss,NS
最近来自芬兰的一项病例对照研究报告了肺炎衣原体TWAR菌株的高抗体滴度与慢性冠心病和急性心肌梗死之间的强相关性。本病例对照研究探讨了C。肺炎免疫球蛋白G抗体滴度和血管造影诊断的冠状动脉疾病。例（n = 461）为血管造影患者，至少有一处冠状动脉病变至少占管腔直径的50%。对照组（n = 95）为无明显冠状动脉疾病的血管造影患者。在年龄和性别标准化后，病例组的几何平均抗体滴度高于对照组（30.0 vs 24.0，p = 0.04）。校正年龄和性别后，高抗体滴度（大于或等于1：64）受试者的冠状动脉疾病估计风险高于低抗体滴度（小于或等于1：8）受试者（相对风险为2.0; 95%置信区间为1.0-4.0）。与高抗体滴度相关的风险在冠状动脉病变≥ 5处的患者中尤为显著（相对风险为2.8，95%可信区间为1.2-7.0）。这项横断面研究的结果支持了C。肺炎和冠状动脉疾病。
A recent case-control study from Finland reported a strong association between high antibody titers to Chlamydia pneumoniae, strain TWAR, and both chronic coronary heart disease and acute myocardial infarction. The current case-control study investigated the relation between C. pneumoniae immunoglobulin G antibody titers and angiographically diagnosed coronary artery disease. Cases (n = 461) were angiography patients with at least one coronary artery lesion occupying at least 50% of the luminal diameter. Controls (n = 95) were angiography patients with no demonstrable coronary artery disease. After standardization for age and gender, the geometric mean antibody titer was higher for cases than for controls (30.0 versus 24.0, p = 0.04). The estimated risk of coronary artery disease, adjusted for age and gender, was greater among subjects with high (greater than or equal to 1:64) antibody titers than among subjects with low (less than or equal to 1:8) antibody titers (relative risk, 2.0; 95% confidence interval, 1.0-4.0). The risk associated with a high antibody titer was particularly great for coronary artery disease with five or more lesions (relative risk, 2.8; 95% confidence interval, 1.2-7.0). The results of this cross-sectional study support an association between infection with C. pneumoniae and coronary artery disease.