Reduced Graphene Oxide Nanosheet for Chemo-photothermal Therapy
Reduced Graphene Oxide Nanosheet for Chemo-photothermal Therapy
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DOI：
10.1021/acs.langmuir.6b00315
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发表时间：
2016-03-22
期刊：
影响因子：
3.9
通讯作者：
Chung, Bong Geun
中科院分区：
文献类型：
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作者：
Cheon, Yeong Ah;Bae, Jun Hyuk;Chung, Bong Geun
蛋白质功能化还原氧化石墨烯(RGO)纳米片在刺激响应型药物传递和控制释放应用中具有重要的应用价值。我们制备了阿霉素(DOX)-牛血清白蛋白(BSA)功能化rGO(DOX-BSA-rGO)纳米片。利用X射线光电子能谱(XPS)和紫外-可见分光光度分析研究了BSA功能化GO纳米片的还原和载药效率。DOX-BSA-rGO纳米片表现出剂量依赖性的细胞摄取，没有任何细胞毒性作用。我们还展示了用DOX-BSA-rGO纳米片治疗的近红外(NIR)诱导的脑瘤细胞的化学-光热治疗。因此，这种DOX-BSA-rGO纳米片可能成为化学-光热治疗应用的有力工具。
The protein-functionalized reduced graphene oxide (rGO) nanosheet is of great interest in stimuli-responsive drug delivery and controlled release applications. We developed doxorubicin (DOX)-loaded bovine serum albumin (BSA)-functionalized rGO (DOX-BSA-rGO) nanosheets. To investigate the reduction of BSA-functionalized GO nanosheets and drug loading efficiency, we used X-ray photoelectron spectroscopy (XPS) and UV-visible spectrophotometer analysis. DOX-BSA-rGO nanosheets exhibited dose-dependent cellular uptake without any cytotoxic effect. We also demonstrated near infrared (NIR)-induced chemo-photothermal therapy of brain tumor cells treated with DOX-BSA-rGO nanosheets. Therefore, this DOX-BSA-rGO nanosheet could be a powerful tool for chemo-photothermal therapy applications.