Frequency-specific alterations of large-scale functional brain networks in patients with Alzheimer's disease.
Frequency-specific alterations of large-scale functional brain networks in patients with Alzheimer's disease.
复制标题
阿尔茨海默病患者大规模功能性大脑网络的频率特异性改变。
DOI：
10.4103/0366-6999.151654
复制
发表时间：
2015-03-05
影响因子：
6.1
通讯作者：
Zhu WZ
中科院分区：
文献类型：
--
作者：
Qin YY;Li YP;Zhang S;Xiong Y;Guo LY;Yang SQ;Yao YH;Li W;Zhu WZ
以往的研究表明，阿尔茨海默病（AD）患者的认知功能障碍可能是由于脑网络拓扑结构的恶化。然而，特定频带的选择是否会影响拓扑特性仍然不清楚。我们的假设是，AD患者的拓扑特性也是频率特异性的。本研究纳入了10名右利手中度AD患者（平均年龄：64.3岁;平均简易精神状态检查[MMSE]：18.0）和10名年龄和性别匹配的健康对照者（平均年龄：63.6岁;平均MMSE：28.2）的静息状态功能磁共振成像数据。在三个不同的频带（0.01-0.06 Hz、0.06-0.11 Hz和0.11-0.25 Hz），在宽范围的阈值内计算全局效率、聚类系数（CC）、特征路径长度（CpL）和“小世界”属性，并在每组内取平均值。在较低的频段（0.01-0.06 Hz，0.06-0.11 Hz），AD患者的整体效率，CC和“小世界”属性与对照组相比下降。而在较高的频段（0.11-0.25 Hz），CpL长得多，“小世界”属性被破坏，特别是在较高的阈值。不同频段的拓扑性质发生变化，表明与AD相关的全球和局部功能组织的破坏的存在。本研究表明，AD患者大规模脑功能网络的拓扑结构改变具有频率依赖性，从而为今后相关研究的最佳频率选择提供了基础支持。
Previous studies have indicated that the cognitive deficits in patients with Alzheimer's disease (AD) may be due to topological deteriorations of the brain network. However, whether the selection of a specific frequency band could impact the topological properties is still not clear. Our hypothesis is that the topological properties of AD patients are also frequency-specific. Resting state functional magnetic resonance imaging data from 10 right-handed moderate AD patients (mean age: 64.3 years; mean mini mental state examination [MMSE]: 18.0) and 10 age and gender-matched healthy controls (mean age: 63.6 years; mean MMSE: 28.2) were enrolled in this study. The global efficiency, the clustering coefficient (CC), the characteristic path length (CpL), and “small-world” property were calculated in a wide range of thresholds and averaged within each group, at three different frequency bands (0.01–0.06 Hz, 0.06–0.11 Hz, and 0.11–0.25 Hz). At lower-frequency bands (0.01–0.06 Hz, 0.06–0.11 Hz), the global efficiency, the CC and the “small-world” properties of AD patients decreased compared to controls. While at higher-frequency bands (0.11–0.25 Hz), the CpL was much longer, and the “small-world” property was disrupted in AD, particularly at a higher threshold. The topological properties changed with different frequency bands, suggesting the existence of disrupted global and local functional organization associated with AD. This study demonstrates that the topological alterations of large-scale functional brain networks in AD patients are frequency dependent, thus providing fundamental support for optimal frequency selection in future related research.