Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics.
Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics.
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DOI：
10.1021/jm400539d
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发表时间：
2013-11-14
影响因子：
7.3
通讯作者：
Papapetropoulos A
中科院分区：
文献类型：
--
作者：
Rekowski MVW;Kumar V;Zhou Z;Moschner J;Marazioti A;Bantzi M;Spyroulias GA;van den Akker F;Giannis A;Papapetropoulos A
Recently the structure of BAY58-2667 bound to the Nostoc sp. H-NOX domain was published. Based on this structural information, we designed BAY58-2667 derivatives and tested their effects on soluble guanylyl cyclase (sGC) activity. Derivative 20 activated sGC 4.8-fold more than BAY 58-2667. Co-crystalization of 20 with the Ns H-NOX domain revealed that the increased conformational distortion at the C-terminal region of αF helix containing 110-114 residues contributes to the higher activation triggered by 20.
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影响因子：
2.9
作者：
Kumar V;Martin F;Hahn MG;Schaefer M;Stamler JS;Stasch JP;van den Akker F
通讯作者：
van den Akker F
影响因子：
37.8
作者：
HARRISON, DG;BATES, JN
通讯作者：
BATES, JN
影响因子：
3.5
作者：
Goodyer, CLM;Chinje, EC;Threadgill, MD
通讯作者：
Threadgill, MD
影响因子：
37.8
作者：
Stasch JP;Pacher P;Evgenov OV
通讯作者：
Evgenov OV
影响因子：
5.2
作者：
Lin, Jinzhen;Gerstenberger, Brian S.;Stessman, Nhu Y. T.;Konopelski, Joseph P.
通讯作者：
Konopelski, Joseph P.