Cyclohexadepsipeptides from the Filamentous Fungus Acremonium sp BCC 2629
Cyclohexadepsipeptides from the Filamentous Fungus Acremonium sp BCC 2629
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DOI：
10.1002/hlca.201100482
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发表时间：
2012-06-01
影响因子：
1.8
通讯作者：
Isaka, Masahiko
中科院分区：
文献类型：
--
作者：
Bunyapaiboonsri, Taridaporn;Vongvilai, Pornrapee;Isaka, Masahiko
七种新的环己缩酚肽，beauvenniatins F、G1、G2、G3、H1、H2和H3（分别为17），分离自真菌枝顶孢属（Acremonium sp. BCC 2629）的培养物。它们的结构通过广泛的光谱分析鉴定。绝对构型通过其酸水解产物的HPLC分析来解决。评价了它们对结核分枝杆菌H37 Ra和恶性疟原虫K1的生物活性;各自的MIC和IC 50值在微摩尔范围内。
Seven new cyclohexadepsipeptides, beauvenniatins F, G1, G2, G3, H1, H2, and H3 (17, resp.), were isolated from cultures of the fungus Acremonium sp. BCC 2629. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations were addressed by HPLC analyses of their acid hydrolysates. Their biological activities were evaluated against Mycobacterium tuberculosis H37Ra and Plasmodium falciparum K1; the respective MIC and IC50 values were in the micromolar range.