Agr function is upregulated by photodynamic therapy for Staphylococcus aureus and is related to resistance to photodynamic therapy
Agr function is upregulated by photodynamic therapy for Staphylococcus aureus and is related to resistance to photodynamic therapy
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金黄色葡萄球菌光动力治疗可上调 Agr 功能，且与光动力治疗耐药相关
DOI：
10.1111/1348-0421.12070
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发表时间：
2013
影响因子：
2.6
通讯作者：
I. Bang
中科院分区：
文献类型：
--
作者：
H. Park;Y. Moon;H. Yoon;Yoon Mee Park;J. Yoon;I. Bang
光动力疗法（PDT）被认为是多药耐药病原体抗菌治疗的可行替代方案。然而，细菌对PDT产生的光氧化应激的反应机制在很大程度上仍然未知。在本文中，显示辅助基因调节剂Agr参与金黄色葡萄球菌对由激光诱导的PDT与光敏剂二氢卟酚e6产生的光氧化应激的响应。转录谱显示，亚致死PDT诱导了一般的应激反应，也激活了Agr依赖的基因调控。此外，突变体S.缺乏Agr功能的金黄色葡萄球菌对两种具有更高能量密度的独立PDT条件表现出过敏性，表明Agr依赖性S.金黄色葡萄球菌对PDT的耐药性。
Photodynamic therapy (PDT) has been considered a feasible alternative for antimicrobial therapy of multidrug‐resistant pathogens. However, bacterial response mechanisms against PDT‐generated photo‐oxidative stress remain largely unknown. Herein, it is shown that the accessory gene regulator Agr is involved in Staphylococcus aureus response to photo‐oxidative stress generated by laser‐induced PDT with the photosensitizer chlorin e6. Transcriptional profiling revealed that sublethal PDT induces a general stress response and also activates Agr‐dependent gene regulation. Moreover, mutant S. aureus lacking Agr function showed hypersusceptibility to two independent PDT conditions with higher energy densities, demonstrating Agr‐dependent S. aureus resistance against PDT.
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影响因子：
3.3
作者：
Dai, Tianhong;Huang, Ying-Ying;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
影响因子：
4.4
作者：
M. C. Booth;R. V. Atkuri;S. Nanda;J. Iandolo;Michael S. Gilmore
通讯作者：
M. C. Booth;R. V. Atkuri;S. Nanda;J. Iandolo;Michael S. Gilmore
影响因子：
2.8
作者：
Cassat, James;Dunman, Paul M.;Smeltzer, Mark S.
通讯作者：
Smeltzer, Mark S.
影响因子：
6.4
作者：
Fowler, VG;Sakoulas, G;Bayer, AS
通讯作者：
Bayer, AS