Mixing and matching nuclear envelope remodeling and spindle assembly strategies in the evolution of mitosis
Mixing and matching nuclear envelope remodeling and spindle assembly strategies in the evolution of mitosis
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DOI：
10.1016/j.ceb.2016.03.016
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发表时间：
2016-08-01
影响因子：
7.5
通讯作者：
Oliferenko, Snezhana
中科院分区：
文献类型：
--
作者：
Makarova, Maria;Oliferenko, Snezhana
在真核生物中，细胞基因组被包裹在一个称为细胞核的膜结合的细胞器中。细胞核将基因组复制、修复和表达区分开来，使这些活动与蛋白质合成和其他代谢过程分开。每一次增殖分裂，复制的染色体必须在子细胞之间等分，这需要基于微管的有丝分裂纺锤体的组装和核重塑之间的精确协调。在这里，我们回顾了现代真核生物用来管理这些过程的各种令人惊讶的策略，并讨论了可能导致进化中这种多样性出现的可能机制。
In eukaryotes, cellular genome is enclosed inside a membrane-bound organelle called the nucleus. The nucleus compartmentalizes genome replication, repair and expression, keeping these activities separated from protein synthesis and other metabolic processes. Each proliferative division, the duplicated chromosomes must be equipartitioned between the daughter cells and this requires precise coordination between assembly of the microtubule-based mitotic spindle and nuclear remodeling. Here we review a surprising variety of strategies used by modern eukaryotes to manage these processes and discuss possible mechanisms that might have led to the emergence of this diversity in evolution.