Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.
Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.
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DOI：
10.1186/s12979-016-0059-y
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Aleksandrova K
中科院分区：
文献类型：
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作者：
Chuang SC;Boeing H;Vollset SE;Midttun Ø;Ueland PM;Bueno-de-Mesquita B;Lajous M;Fagherazzi G;Boutron-Ruault MC;Kaaks R;Küehn T;Pischon T;Drogan D;Tjønneland A;Overvad K;Quirós JR;Agudo A;Molina-Montes E;Dorronsoro M;Huerta JM;Barricarte A;Khaw KT;Wareham NJ;Travis RC;Trichopoulou A;Lagiou P;Trichopoulos D;Masala G;Agnoli C;Tumino R;Mattiello A;Peeters PH;Weiderpass E;Palmqvist R;Ljuslinder I;Gunter M;Lu Y;Cross AJ;Riboli E;Vineis P;Aleksandrova K
20年前，血清新喋呤水平升高曾被描述为老年患者。新喋呤是一种全身适应性免疫激活的生物标志物，可能与代谢综合征(METS)有关。在欧洲癌症与营养前瞻性调查(EPIC)中招募的594名参与者进行了腰围、甘油三酯、高密度脂蛋白胆固醇(HDLC)、收缩压和舒张压、糖化血红蛋白(METS定义成分)和血浆总新喋呤浓度的测量。较高的新喋呤总浓度与高密度脂蛋白胆固醇的降低有关(男性为9.7nmol%，p <； 0.01，女性为9.2%，p <； 0.01)，而与METS的其他成分以及总体的METS没有相关性(按10nmoL/L：OR = 1.42，95%CI = 0.85-2.39；OR = 1.38，95%CI = 0.79-2.43)。这些数据表明，较高的新喋呤总浓度与HDLC降低有关，但与总体METS无关。
Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43). These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.