Young's modulus and hardness of human trabecular bone with bisphosphonate treatment durations up to 20 years.
Young's modulus and hardness of human trabecular bone with bisphosphonate treatment durations up to 20 years.
复制标题
双膦酸盐治疗持续时间长达 20 年的人体骨小梁的杨氏模量和硬度。
DOI：
10.1007/s00198-018-4760-x
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Malluche,HH
中科院分区：
文献类型：
--
作者：
Pienkowski,D;Wood,CL;Malluche,HH
总结分析了接受双膦酸盐治疗1 - 20年的骨质疏松症患者的骨模量。模量增加，在第一个6年的治疗，并保持不变aftershare.IntroductionBisphosphonates被广泛用于治疗骨质疏松症，但治疗时间和骨质量之间的关系尚不清楚。由于材料的性质部分地决定骨质量，本研究量化了人骨模量和硬度与bisphosphonate treatment duty.MethodsIliac嵴骨样本从一个连续的病例系列的86个骨质疏松的高加索妇女连续治疗口服双膦酸盐1.1-20年进行了组织学评价，以评估骨转换，然后使用纳米压痕测试。测量杨氏模量和硬度，并通过统计建模将其与双磷酸盐治疗时间相关。结果所有骨样本的骨转换率均较低。统计模型表明，随着双膦酸盐处理时间的增加，模量和硬度增加，达到峰值，并趋于平稳。这些模型使用二次项来模拟双膦酸盐治疗1 - 6年的模量增加，使用线性项来模拟治疗6 - 20年的模量平台。发生二次线性过渡（接合点）的治疗持续时间也取决于小梁位置。硬度增加，并在12.4年的治疗达到峰值，它保持不变，为未来7.6年的治疗和不敏感的小梁location.ConclusionsBone模量增加与双膦酸盐治疗持续时间长达6年，没有额外的模量增加发生后6年的治疗。虽然硬度增加，在12.4年达到峰值，并在接下来的7.6年BP治疗中保持不变，但硬度的临床相关性仍不清楚。
SummaryBone modulus from patients with osteoporosis treated with bisphosphonates for 1 to 20 years was analyzed. Modulus increases during the first 6 years of treatment and remains unchanged thereafter.IntroductionBisphosphonates are widely used for treating osteoporosis, but the relationship between treatment duration and bone quality is unclear. Since material properties partially determine bone quality, the present study quantified the relationship between human bone modulus and hardness with bisphosphonate treatment duration.MethodsIliac crest bone samples from a consecutive case series of 86 osteoporotic Caucasian women continuously treated with oral bisphosphonates for 1.1–20 years were histologically evaluated to assess bone turnover and then tested using nanoindentation. Young’s modulus and hardness were measured and related to bisphosphonate treatment duration by statistical modeling.ResultsAll bone samples had low bone turnover. Statistical models showed that with increasing bisphosphonate treatment duration, modulus and hardness increased, peaked, and plateaued. These models used quadratic terms to model modulus increases from 1 to 6 years of bisphosphonate treatment and linear terms to model modulus plateaus from 6 to 20 years of treatment. The treatment duration at which the quadratic–linear transition (join point) occurred also depended upon trabecular location. Hardness increased and peaked at 12.4 years of treatment; it remained constant for the next 7.6 years of treatment and was insensitive to trabecular location.ConclusionsBone modulus increases with bisphosphonate treatment durations up to 6 years, no additional modulus increases occurred after 6 years of treatment. Although hardness increased, peaked at 12.4 years and remained constant for the next 7.6 years of BP treatment, the clinical relevance of hardness remains unclear.