Enhanced biological functions of human mesenchymal stem cell aggregates incorporating E-cadherin-modified PLGA microparticles
Enhanced biological functions of human mesenchymal stem cell aggregates incorporating E-cadherin-modified PLGA microparticles
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E-钙粘蛋白修饰的 PLGA 微粒增强人间充质干细胞聚集体的生物学功能
DOI：
10.1002/adhm.201670082
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发表时间：
2016
影响因子：
10
通讯作者：
YangJun
中科院分区：
文献类型：
--
作者：
ZhangYan;MaoHongli;Chao Gao;Suhua Li;Qizhi Shuai;Jianbin Xu;Ke Xu;Lei Cao;LangRen;Gu Zhongwei;Akaike Toshihiro;YangJun
Jun Yang 及其同事制造了 E-钙粘蛋白修饰的聚乳酸-乙醇酸 (hE-cad-PLGA) 微粒，然后介导人间充质干细胞 (MSC) 的 3D 细胞聚集体（见第 1949 页）。 hE-cad-Fc基质和PLGA微粒通过激活EGFR、AKT和ERK1/2信号通路协同调节MSC的增殖和生物活性因子的分泌。 hE-cad-PLGA 微粒为扩展基于多能干细胞的临床应用提供了一条新途径。
E-cadherin-modified poly (lactic-co-glycolic acid)(hE-cad-PLGA) microparticles were fabricated and then mediated the 3D cell aggregates of human mesenchymal stem cells (MSCs) on page 1949 by Jun Yang and co-workers. The hE-cad-Fc matrix and the PLGA microparticles synergistically regulate the proliferation and bioactive factors secretions of MSCs by activating EGFR, AKT and ERK1/2 signaling pathways. The hE-cad-PLGA microparticles offer a novel route to expand multipotent stem cell-based clinical applications.