Elevated Serum Triglyceride and Retinol-Binding Protein 4 Levels Associated with Fructose-Sweetened Beverages in Adolescents
Elevated Serum Triglyceride and Retinol-Binding Protein 4 Levels Associated with Fructose-Sweetened Beverages in Adolescents
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DOI：
10.1371/journal.pone.0082004
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发表时间：
2014-01-27
期刊：
影响因子：
3.7
通讯作者：
Lee, Chien-Hung
中科院分区：
文献类型：
--
作者：
Chan, Te-Fu;Lin, Wei-Ting;Lee, Chien-Hung
背景：含糖饮料(SSB)中果糖的代谢作用与新生脂肪生成和尿酸(UA)的产生有关。目的：研究饮用SSB对台湾青少年血脂和视黄醇结合蛋白4(RBP4)的生物学影响。方法：从大规模横断面研究中随机抽取200名有代表性的青少年(98名男孩和102名女孩)，评估其人体测量参数和生化结果。结果：SSB消费量的增加与腰围、臀围、体重指数(BMI)值以及血清UA、甘油三酯(TG)和RBP4水平相关。每天饮用500毫升含高果糖玉米糖浆(HFCS)的半甜到重甜饮料的青少年，甘油三酯和RBP4水平分别比不饮酒者高22.7 mg/dl和13.92 ng/ml。高尿酸血症的HFCS饮用者的甘油三酯水平高于UA水平正常的HFCS饮用者(98.6比81.6 mg/dl)。超重/肥胖青少年摄入富含HFCS的SSB和高BMI(>；=24)交互作用地增加了RBP4水平。在饮用者中，循环中的RBP4水平与体重相关结果、甘油三酯和尿酸浓度显著相关(r=0.253~0.404)，而在不饮酒者中则不相关。结论：大量饮用富含HFCS的饮料与较高的TG和RBP4水平相关。高尿酸血症可能会加剧富含HFCS的SSB摄入对升高的甘油三酯水平的影响，在超重和肥胖的青少年中，高BMI可能会改变果糖对循环中较高的RBP4水平的作用。
Background: The metabolic effect of fructose in sugar-sweetened beverages (SSB) has been linked to de novo lipogenesis and uric acid (UA) production.Objectives: This study investigated the biological effects of SSB consumption on serum lipid profiles and retinol-binding protein 4 (RBP4) among Taiwanese adolescents.Methods: We evaluated the anthropometric parameters and biochemical outcomes of 200 representative adolescents (98 boys and 102 girls) who were randomly selected from a large-scale cross-sectional study. Data were analyzed using multiple regression models adjusted for covariates.Results: Increased SSB consumption was associated with increased waist and hip circumferences, body mass index (BMI) values and serum UA, triglyceride (TG) and RBP4 levels. Adolescents who consumed >500 ml/day of beverages half-to-heavily sweetened with high-fructose corn syrup (HFCS) exhibited TG and RBP4 levels 22.7 mg/dl and 13.92 ng/ml higher than non-drinkers, respectively. HFCS drinkers with hyperuricemia had higher TG levels than HFCS drinkers with normal UA levels (98.6 vs. 81.6 mg/dl). The intake of HFCS-rich SSBs and high value of BMI (>= 24) interactively reinforced RBP4 levels among overweight/obese adolescents. Circulating RBP4 levels were significantly correlated with weight-related outcomes and TG and UA concentration among HFCS drinkers (r = 0.253 to 0.404), but not among non-drinkers.Conclusions: High-quantity HFCS-rich beverage consumption is associated with higher TG and RBP4 levels. Hyperuricemia is likely to intensify the influence of HFCS-rich SSB intake on elevated TG levels, and in overweight and obese adolescents, high BMI may modify the action of fructose on higher circulating levels of RBP4.