Effects of oral cocaine on intravenous cocaine discrimination in humans.
Effects of oral cocaine on intravenous cocaine discrimination in humans.
复制标题
口服可卡因对人类静脉注射可卡因歧视的影响。
DOI：
10.1037/1064-1297.15.3.219
复制
发表时间：
2007
影响因子：
2.3
通讯作者：
Schubiner,Howard
中科院分区：
文献类型：
--
作者：
Johanson,Chris-Ellyn;Lundahl,LeslieH;Schubiner,Howard
这项研究旨在评估药物辨别范式作为评估潜在激动剂药物阻断静脉注射可卡因效果的能力的模型。以前的研究已经证明，口服可卡因可以减弱静脉注射可卡因的主观和生理影响，在缺乏治疗可卡因使用障碍的已知有效药物的情况下，采用了一种概念验证方法，即通过急性口服可卡因来阻断静脉注射可卡因的辨别刺激效应。在训练期间，11名可卡因依赖参与者能够区分静脉注射生理盐水和20毫克/70公斤静脉注射可卡因，其中8名参与者完成了研究。训练结束后，参与者在没有意外情况的情况下，在静脉注射不同剂量的可卡因之前60分钟摄入含有安慰剂或300毫克/70公斤可卡因的胶囊。每个剂量的可卡因被给予两次，每次口服预处理条件下一次。培训课程穿插在测试课程中。在每一次治疗中都测量了生理和主观影响。口服可卡因适度增加了静脉注射低剂量可卡因的一些主观和生理影响，而高剂量的效果没有改变。歧视结果也发生了类似的变化。因此，尽管口服可卡因很可能不是一种可行的可卡因依赖治疗药物，但药物歧视模型在评估激动剂治疗药物方面的用处仍不清楚。
This study was designed to evaluate the drug discrimination paradigm as a model for assessing the ability of potential agonist medications to block the effects of intravenous cocaine. Previous research has demonstrated that oral cocaine attenuated the subjective and physiological effects of intravenous cocaine injections, and in the absence of a known efficacious medication for cocaine use disorders, a proof-of-concept approach was used in which cocaine was acutely administered orally to block intravenous cocaine's discriminative-stimulus effects. During training, 11 cocaine-dependent participants were able to discriminate between intravenous saline and 20 mg/70 kg iv cocaine, and 8 of these participants completed the study. After training, participants ingested capsules containing either placebo or 300 mg/70 kg cocaine 60 min prior to the intravenous injection of different doses of cocaine during test sessions with no contingencies in place. Each cocaine dose was administered twice, once under each oral pretreatment condition. Training sessions were interspersed among the test sessions. Physiological and subjective effects were measured throughout each session. Oral cocaine moderately increased some of the subjective and physiological effects of the lower doses of intravenous cocaine, whereas effects at the higher doses were unaltered. Similar changes were seen for the discrimination results. Thus, although oral cocaine given acutely likely is not a viable treatment medication for cocaine dependence, the usefulness of the drug discrimination model in the evaluation of agonist treatment medications remains unclear.(PsycINFO Database Record (c) 2016 APA, all rights reserved)