Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma, nasal type
Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma, nasal type
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DOI：
10.1002/gcc.20245
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发表时间：
2005-11-01
影响因子：
3.7
通讯作者：
Seto, M
中科院分区：
文献类型：
--
作者：
Nakashima, Y;Tagawa, H;Seto, M
自然杀伤（NK）细胞淋巴瘤/白血病是高度侵袭性的淋巴恶性肿瘤，但对其基因组改变知之甚少，因此迫切需要鉴定和分析NK细胞淋巴瘤/白血病。最近，我们开发了我们自己的基于阵列的比较基因组杂交（阵列CGH），平均分辨率为1.3 Mb。我们对27例NK细胞淋巴瘤/白血病病例进行了阵列CGH分析，这些病例根据世界卫生组织分类分为两个疾病组（10例侵袭性NK细胞白血病病例和17例结性NK/T细胞[NK/T]淋巴瘤，鼻型）。我们确定了两组的基因组改变模式的差异。侵袭性NK细胞白血病组与结外NK/T淋巴瘤鼻型组相比，其特征性复发区域为1 q增加，7p15.1-p22.3和17p13.1丢失。特别是1q23.1-q24.2（P = 0.041）和1q31.3-q44（P = 0.003-0.047）的增加以及7p15.1-p22.3（P = 0.012-0.041）和17p13.1（P = 0.012）的丢失在前者中发生的频率显著高于后者。鼻型结旁NK/T淋巴瘤的特征性复发区域与其他组相比，2 q增加，6q16.1-q27、11q22.3-q23.3、5p14.1-p14.3、5 q34-q35.3、1p36.23-p36.33、2p16.1-p16.3、4 q12和4q31.3-q32.1丢失。我们的研究结果有望为淋巴瘤发生的遗传基础和NK细胞淋巴瘤/白血病的临床病理特征提供进一步的见解。(c)2005 Wiley-Liss，Inc.
Natural killer (NK) cell lymphomas/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there is an urgent need for identification and analysis of NK cell lymphomas/leukemias. Recently, we developed our own array-based comparative genomic hybridization (array CGH) with an average resolution of 1.3 Mb. We performed an array CGH analysis for 27 NK-cell lymphoma/leukemia cases that were classified into two disease groups based on the World Health Organization Classification (10 aggressive NK-cell leukemia cases and 17 extranodal NK/T-cell [NK/T] lymphomas, nasal type). We identified the differences in the genomic alteration patterns of the two groups. The recurrent regions characteristic of the aggressive NK-cell leukemia group compared with those of the extranodal NK/T lymphoma, nasal-type group, were gain of 1q and loss of 7p15.1-p22.3 and 17p13.1. In particular, gain of 1q23.1-q24.2 (P = 0.041) and 1q31.3-q44 (P = 0.003-0.047), and loss of 7p15.1-p22.3 (P = 0.012-0.041) and 17p13.1 (P = 0.012) occurred significantly more frequently in the former than in the latter group. Recurrent regions characteristic of the extranodal NK/T lymphoma, nasal-type group, compared with those of the other group were gain of 2q, and loss of 6q16.1-q27, 11q22.3-q23.3, 5p14.1-p14.3, 5q34-q35.3, 1p36.23-p36.33, 2p16.1-p16.3, 4q12, and 4q31.3-q32.1. Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK-cell lymphomas/leukemias. (c) 2005 Wiley-Liss, Inc.