Ovarian status in healthy postmenopausal women: follow-up 12 months after transvaginal ultrasound
Ovarian status in healthy postmenopausal women: follow-up 12 months after transvaginal ultrasound
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DOI：
10.1097/gme.0b013e3181aa1c93
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发表时间：
2009-11-01
影响因子：
2.7
通讯作者：
Walker, Frances
中科院分区：
文献类型：
--
作者：
Bell, Robin J.;Healy, David L.;Walker, Frances
目的：我们之前报道了515名绝经后至少5年无症状妇女经阴道超声（TVU）检测卵巢病变的点患病率。本研究的目的是报告，在同一女性中，卵巢可视化（TVU）的可重复性和卵巢病变的自然史在基线时看到，但没有手术治疗，并评估是否有任何女性在12个月后出现新的卵巢异常。方法：该研究涉及515名绝经后妇女，从社区招募，至少5年的最后一次月经。在基线和12个月后再次评估TVU和血清抑制素和CA-125水平。结果：右侧卵巢和左侧卵巢在两种情况下分别占80%和68%。在49名基线时卵巢病变的妇女中，当时没有接受手术，并进行了随访，12个月后，30名妇女的卵巢病变没有变化。四名女性在12个月内出现了新的卵巢病变。根据基线卵巢外观进行手术的4名妇女和根据随访卵巢外观进行手术的2名妇女均无卵巢恶性肿瘤。结论：在绝经后至少5年的女性中使用TVU是有问题的，因为并非所有女性的卵巢都能被观察到，而且TVU有可能识别出许多良性病变，否则这些病变将无法被发现。在权衡使用TVU作为筛查工具的风险和收益时，这些都是重要的考虑因素。
Objective: We have previously reported on the point prevalence of ovarian lesions detected by transvaginal ultrasound (TVU) in 515 asymptomatic women at least 5 years postmenopause. The aims of this study were to report, in the same women, on the repeatability of visualization of the ovaries (TVU) and the natural history of ovarian lesions seen at baseline but not treated surgically and to assess whether any women developed new ovarian abnormalities 12 months later.Methods: The study involved a cohort of 515 postmenopausal women recruited from the community, at least 5 years past their last period. They were assessed at baseline and again after 12 months with TVU and serum levels of inhibin and CA-125.Results: The right and left ovaries were seen on both occasions in 80% and 68% of women, respectively. Of the 49 women who had an ovarian lesion at baseline, did not undergo surgery at that time, and had a follow-up TVU, the lesion was unchanged 12 months later in 30 women. Four women developed a new ovarian lesion within the 12 months. None of the f4 women who underwent surgery on the basis of the ovarian appearance at baseline, or the 2 who had surgery on the basis of the ovarian appearance at follow-up, had an ovarian malignancy.Conclusions: The use of TVU in women at least 5 years after menopause is problematic because the ovaries cannot be visualized in all women and because TVU has the potential to identify many benign lesions that would otherwise remain undetected. These are important considerations in weighing up the risks and benefits of using TVU as a screening tool.