Unintended pregnancies and exposure to potential human teratogens
Unintended pregnancies and exposure to potential human teratogens
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DOI：
10.1002/bdra.20132
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发表时间：
2005-04-01
影响因子：
--
通讯作者：
Koren, G
中科院分区：
文献类型：
--
作者：
Han, JY;Nava-Ocampo, AA;Koren, G
背景技术背景：我们的目的是调查与意外怀孕相关的危险因素，以及意外怀孕和潜在致畸暴露之间的关联。方法：在韩国首尔三星第一医院妇产科和妇女保健中心的妇女中进行了一项横断面调查。获得人口统计学数据、产科史、社会经济状况、怀孕意愿和暴露于潜在致畸剂的情况。结果：共纳入1354名妇女，中位年龄为29岁，中位孕龄为29周。其中，高中以上文化程度占74.2%，早孕占77.3%，意外妊娠占48%。在逻辑回归分析中，年龄小于24岁的女性发生意外妊娠的相对风险（RR）为2.5（95%置信区间[CI]，1.3-4.7），家庭月收入水平较低的女性发生意外妊娠的相对风险为1.3（95% CI，1.0-1.6）。意外怀孕的女性的RR为1.9（95% Cl，1.5-2.5），3.0（95% Cl，2.0-4.5），1.5（95% CI，1.0-2.3），2.9（95% Cl，1.1-7.2）和2.0（95% CI，1.62.4）分别暴露于酒精、药物、吸烟、X射线或其中任何一种，在怀孕的前三个月。结论：家庭月收入水平较低的年轻女性更容易发生意外怀孕。产前咨询应特别推荐的妇女意外怀孕，以评估他们是否已暴露于潜在的致畸剂。出生缺陷研究（A部分）73：245-248，2005年。(c)2005 Wiley-Liss，Inc.
BACKGROUND: We aimed to investigate the risk factors associated with unintended pregnancies as well as the association between unintended pregnancies and potential teratogenic exposures. METHODS: A cross-sectional survey was performed among women attending the Maternity School of the Samsung Cheil Hospital and Women's Health Care Center in Seoul, Korea. Demographic data, obstetric history, socioeconomic status, intention to become pregnant, and exposure to potential teratogens were obtained. RESULTS: A total of 1354 women with median age of 29 years and median gestational age of 29 weeks were included. Of these, an educational level above high school was 74.2%, primigravida was 77.3% and unintended pregnancy was 48%. In the logistic regression analysis, women younger than 24 years of age had a relative risk (RR) of 2.5 (95% confidence interval [CI], 1.3-4.7) of having an unintended pregnancy and women with lower household monthly income level had a RR of 1.3 (95% Cl, 1.0-1.6). Women with unintended pregnancies had an RR of 1.9 (95% Cl, 1.5-2.5), 3.0 (95% Cl, 2.0-4.5), 1.5 (95% CI, 1.0-2.3), 2.9 (95% Cl, 1.1-7.2), and 2.0 (95% Cl, 1.62.4) of being exposed to alcohol, medications, cigarette smoking, X-rays, or to any of these, respectively, during the first trimester of pregnancy. CONCLUSIONS: Unintended pregnancies are more likely to occur among young women with a lower household monthly income level. Prenatal counseling should be especially recommended for women with unintended pregnancies in order to evaluate whether they have been exposed to potential teratogenic agents. Birth Defects Research (Part A) 73:245-248, 2005. (c) 2005 Wiley-Liss, Inc.