Periodontal pathogens produce quorum sensing signal molecules
Periodontal pathogens produce quorum sensing signal molecules
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DOI：
10.1128/iai.69.5.3431-3434.2001
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发表时间：
2001-05-01
影响因子：
3.1
通讯作者：
Alsina, M
中科院分区：
文献类型：
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作者：
Frias, J;Olle, E;Alsina, M
测试了在牙菌斑组成中重要的不同种类的细菌的细胞外自诱导物样活性的产生，所述细胞外自诱导物样活性刺激哈氏弧菌中发光基因的表达。发现中间普雷沃氏菌、具核梭杆菌和牙龈卟啉单胞菌的几种菌株产生这种活性。有趣的是，这些细菌属于相同的系统发育组，它们是牙周病发展中重要的牙周病原体。它们特异性地从哈维氏弧菌产生细胞外信号分子相关的自诱导物-2。然而，它们似乎不能产生酰基高丝氨酸内酯的同系物。此外，大肠杆菌DH5 α可以通过引入与luxS基因具有高度同源性的牙龈卟啉单胞菌基因（称为luxS（P.g. *））来补充。
Different species of bacteria important in the composition of dental plaque were tested for production of extracellular autoinducer like activities that stimulate the expression of the luminescence genes in Vibrio harveyi. Several strains of Prevotella intermedia, Fusobacterium nucleatum, and Porphyromonas gingivalis were found to produce such activities. Interestingly, these bacteria belong to the same phylogenetic group, and they are periodontal pathogens important in the development of periodontal disease. They specifically produce extracellular signaling molecule related autoinducer-2 from V.haveyi. Nevertheless, they seem to be unable to produce homologues of acyl-homoserine lactones. Furthermore, Escherichia coli DH5 alpha can be complemented by the introduction of a P, gingivalis gene with high homology to the luxS gene, which has been called luxS(P.g.*).