THE EFFECT OF CHOLECYSTOKININ ON THE HUMAN GALL BLADDEE
THE EFFECT OF CHOLECYSTOKININ ON THE HUMAN GALL BLADDEE
复制标题
胆囊收缩素对人胆的作用
DOI：
10.1210/endo-14-5-343
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发表时间：
1930
期刊：
影响因子：
4.8
通讯作者：
B. H. Orndoff
中科院分区：
文献类型：
--
作者：
A. Ivy;G. E. Drewyer;B. H. Orndoff
在先前的研究（1）（2）（3）（4）中，已进行了以下观察：（a）可以提取上部肠粘膜，以产生静脉注射时导致犬和猫胆囊收缩和排空的产品。(b)本文用肉眼观察了狗胆囊的收缩，并制作了动态图像。(c)胆囊的收缩和排空是由于特定物质的作用，因为它已被证明不是由于肝脏体积的变化、血压的变化或邻近结构的收缩，并且因为活性成分只能从肠和胃粘膜中提取。(d)在交叉循环实验中，已经表明，将酸放入一只动物的十二指肠不仅会导致该动物的胆囊收缩，而且大约八分钟后会导致第二只动物的胆囊收缩。这些观察使我们得出结论，激素机制是关注...
In previous studies (1) (2) (3) (4) the following observations have been made: (a) The upper intestinal mucosa can be extracted so as to yield a product which on intravenous injection causes the gall bladder of the dog and cat to contract and evacuate. (b) The contraction of the gall bladder in dogs has been observed visually and moving pictures have been made. (c) The contraction and evacuation of the gall bladder is due to the effect of a specific substance, since it has been shown not to be due to a change in liver volume, a change in blood pressure, or contraction of adjacent structures, and since the active principle can be extracted only from the intestinal and gastric mucosa. (d) In cross-circulation experiments it has been shown that acid placed into the duodenum of one animal not only caused the gall bladder of that animal to contract, but about eight minutes later caused the gall bladder of the second animal to contract. These observations lead us to conclude that a hormone mechanism was concern...