New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration
New roles of G protein-coupled receptor kinase 2 (GRK2) in cell migration
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DOI：
10.4161/cam.3.1.7149
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Mayor, Federico, Jr.
中科院分区：
文献类型：
--
作者：
Penela, Petronila;Ribas, Catalina;Mayor, Federico, Jr.
G蛋白偶联受体激酶2 （GRK2）最初被确定为与β -阻滞蛋白一起在多种G蛋白偶联受体（GPCR）的调控中起关键作用。进一步的研究揭示了一个复杂的GRK2相互作用组，其中包括多种与细胞运动相关的蛋白质，以及GRK2激酶活性在抑制趋化因子诱导的免疫细胞迁移中的作用。此外，我们最近报道了GRK2正调控上皮细胞类型和成纤维细胞中整合素和鞘氨醇-1-磷酸依赖的运动，作为支架分子。我们认为GRK2水平与细胞迁移的正相关或负相关将取决于细胞类型、通过质膜受体作用的特定刺激或信号传导环境，从而导致GRK2与细胞迁移相关信号体相互作用的不同网络。
G protein-coupled receptor kinase 2 (GRK2) was initially identified as a key player, together with beta-arrestins, in the regulation of multiple G protein-coupled receptors (GPCR). Further research has revealed a complex GRK2 interactome, that includes a variety of proteins related to cell motility, and a role for GRK2 kinase activity in inhibiting chemokine-induced immune cell migration. In addition, we have recently reported that GRK2 positively regulates integrin and sphingosine-1-phosphate-dependent motility in epithelial cell types and fibroblasts, acting as a scaffold molecule. We suggest that the positive or negative correlation of GRK2 levels with cell migration would depend on the cell type, specific stimuli acting through plasma membrane receptors, or on the signalling context, leading to differential networks of interaction of GRK2 with cell migration-related signalosomes.