Brachial-ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome
Brachial-ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome
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DOI：
10.1253/circj.69.815
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发表时间：
2005-07-01
影响因子：
3.3
通讯作者：
Yamashina, A
中科院分区：
文献类型：
--
作者：
Tomiyama, H;Koji, Y;Yamashina, A
虽然一种非常简单的测量臂踝脉搏波速度（baPWV）的方法已经在临床环境中可用，但baPWV是否可以预测未来的心血管事件仍然不确定。我们研究了baPWV是否是急性冠脉综合征（ACS）患者心血管事件的预测因子。方法与结果对215例ACS患者进行了baPWV测定。在随访期间（26个月，10个月），46例患者发生了住院后心血管事件（18例患者发生了重大事件（如中风、心力衰竭或心源性死亡），28例患者发生了冠状动脉再介入治疗）。受试者工作特征曲线显示，baPWV预测住院后心血管事件的最佳截止点为17.00m/s，预测主要心血管事件的最佳截止点为18.00m/s。在对影响预后的常规危险因素进行调整后，多因素Cox比例风险模型显示，baPWV的两个截断点对住院后事件的危险比均为5.47(2.69-11.09)，对主要心血管事件的危险比均为9.22（2.78-30.56）。结论baPWV是ACS患者预后的简单预测因子，独立于ACS的常规危险因素。
Background Although a very simple method of measuring brachial-ankle pulse wave velocity (baPWV) has become available in a clinical setting, whether baPWV can predict future cardiovascular events remains uncertain. We examined whether baPWV is a predictor of cardiovascular events in patients with acute coronary syndrome (ACS).Methods and Results baPWV measurement was performed in 215 consecutive patients with ACS. During the follow-up period (26 10 months), 46 patients experienced post-hospitalization cardiovascular events (18 patients experienced a major event (eg, stroke, re-admission for heart failure or cardiac death), and 28 patients experienced coronary re-intervention). A receiver operating characteristic curve demonstrated that the best cutoff point of a baPWV for predicting a post-hospitalization cardiovascular event was 17.00m/s and that for predicting a major cardiovascular event was 18.00m/s. After the adjustment for the conventional risk factors influencing the prognosis, a multivariate Cox proportional hazards model demonstrated that both cut-off points of baPWV had a significant hazard ratio for a post-hospitalization event: 5.47 (2.69-11.09) and for a major cardiovascular event: 9.22 (2.78-30.56).Conclusions baPWV is a simple predictor of the prognosis of patients with ACS that is independent of conventional risk factors for ACS.