Microflora in oral ecosystems in subjects with radiation-induced hyposalivation
Microflora in oral ecosystems in subjects with radiation-induced hyposalivation
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DOI：
10.1111/j.1601-0825.2007.01416.x
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发表时间：
2008-09-01
期刊：
影响因子：
3.8
通讯作者：
Fagerberg-Mohlin, B.
中科院分区：
文献类型：
--
作者：
Almstahl, A.;Wikstrom, M.;Fagerberg-Mohlin, B.
目的：分析 13 名齿状受试者、放疗完成后 6-8 个月（RT 组）和 13 名匹配对照者特定口腔部位的微生物菌群。 材料和方法：采用重复采样和培养技术对舌头、颊粘膜、前庭、龈上菌斑和龈下区域的微生物菌群进行分析。还进行了一项临床检查。结果：54% 的 RT 受试者和 15% 的对照组的一个或多个部位发现白色念珠菌。在三名 RT 受试者中，在所有四个分析部位都发现了白色念珠菌。一个意外的发现是，所有 RT 受试者中都发现了肠球菌，其中 38% 的受试者中肠球菌数量较多。所有对照均未携带肠球菌。在龈上菌斑中，乳酸杆菌属。在 92% 的 RT 受试者中检测到乳酸菌的数量和比例。与对照相比非常高。 31% 的 RT 受试者中检测到大量变形链球菌，而 23% 的人未检测到。 结论：微生物结果解释了为什么一些 RT 受试者对口腔疾病的易感性增加，并强调在为 RT 受试者规划口腔健康预防护理时，位点特异性微生物分析是重要的诊断工具。
AIM: To analyse the microbial flora in specific oral sites in 13 dentate subjects, 6-8 months after completed radiation therapy (RT group) and in 13 matched controls.MATERIAL AND METHODS: The microflora on the tongue, buccal mucosa, vestibulum, supragingival plaque and subgingival region was analysed using duplicate sampling and cultivation technique. A clinical examination was also performed.RESULTS: Candida albicans was found in one or more sites in 54% of the RT subjects and in 15% of the controls. In three RT subjects, C. albicans was found at all four sites analysed. An unexpected finding was that enterococci were found in all RT subjects and in high number in 38%. None of the controls harboured enterococci. In supragingival plaque, Lactobacillus spp. were detected in 92% of the RT subjects and the number and proportion of Lactobacillus spp. were extremely high compared with the controls. Mutans streptococci were detected in high numbers in 31% of the RT subjects, while they were not detected in 23%.CONCLUSION: The microbial results explain why some RT subjects have an increased susceptibility to oral diseases and stress that site-specific microbial analysis is an important diagnostic tool when planning oral health preventive care for RT subjects.