Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer
Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer
复制标题
DOI：
10.1002/lsm.20177
复制
发表时间：
2005-06-01
影响因子：
2.4
通讯作者：
Hetzel, FW
中科院分区：
文献类型：
--
作者：
Huang, Z;Chen, Q;Hetzel, FW
背景和目的：研究了tokad （pd - bacteriopophhoride, WST09）介导的光动力疗法（PDT），作为开发治疗前列腺癌的替代方法的一部分。研究设计/材料与方法：以犬自发性前列腺癌和正常前列腺癌为动物模型。通过静脉滴注光敏剂和二极管激光（763 nm）照射前列腺进行间质PDT。pdt后1周切除前列腺，进行组织病理学检查。研究了药物剂量和光剂量对一期和二期PDT的影响。采用高效液相色谱法研究药代动力学。使用灌注CT扫描评估PDT病变的可行性也进行了评估。结果：图卡德是一种血管作用药物，在血液循环中清除迅速。在正常和癌前列腺中，tookad - pdt诱导的病变以明显的出血性坏死为特征。结论：Tookad-PDT通过其血管作用在前列腺组织消融中具有良好的效果。(c) 2005Wiley-Liss, Inc。
Background and Objectives: Photodynamic therapy (PDT) mediated with Tookad (Pd-bacteriopheophorbide, WST09) was investigated pre-clinically as part of a program to develop an alternative modality for treating prostate cancer.Study Design/Materials and Methods: Spontaneous canine prostate cancer and normal canine prostate were used as the animal models. Interstitial PDT was performed by IV infusion of the photosensitizer and irradiating the prostates with a diode laser (763 nm). The prostates were harvested 1-week post-PDT and subjected to histopathologic examinations. The effects of the drug doses and light doses were studied for one- and two-session PDT. Pharmacokinetics were studied using HPLC assay. The feasibility of using perfusing CT scans for assessing PDT lesions was also evaluated.Results: Tookad is a vascular-acting drug and clears rapidly from the circulation. Tookad-PDT-induced lesions, in both normal and cancerous prostates, were characterized by marked hemorrhagic necrosis.Conclusions: Tookad-PDT is very effective in ablating prostatic tissue through its vascular effects. (c) 2005Wiley-Liss, Inc.