STRUCTURE AND FUNCTION OF COLD RECEPTORS
STRUCTURE AND FUNCTION OF COLD RECEPTORS
复制标题
DOI：
10.1007/bf01061945
复制
发表时间：
1974-01-01
影响因子：
4.5
通讯作者：
DURING, MV
中科院分区：
文献类型：
--
作者：
HENSEL, H;ANDRES, KH;DURING, MV
传入脉冲被记录在猫鼻子皮肤的冷热感受器的单个纤维上。用微热模在显微镜下仔细检测受体的特异性和接受野的定位。每一根纤维服务于一个点状的接受野。通过在受体两侧的皮肤上插入两根细不锈钢丝，在不损伤神经末梢的情况下标记出该区域。通过光镜和电子显微镜对半薄和超薄连续切片的研究发现，在每个冷斑下面都有一个真皮乳头，其中包含一个小的有髓纤维，分为许多无髓末梢。靠近表皮的受体分支离开它们的雪旺细胞包膜，穿透上皮的基底层，它们的尖端内陷到基底上皮细胞的细胞质中。上皮的基底层与受体轴突的基底层融合。受体轴突含有大量的线粒体、糖原颗粒和丝状受体基质，其中有大小不一的囊泡。所描述的结构在温暖点下面是不存在的。除了冷感受器外，梅克尔细胞神经突复合体和片状包裹末梢也被发现是已知的机械感受器。
Afferent impulses were recorded from single fibers serving cold and warm receptors in the skin of the cat's nose. The receptors were carefully tested for specificity and the receptive fields localized under the microscope with a microthermode. Each single fiber served one spot-like receptive field. The field was marked without damaging the nerve ending by inserting two thin stainless steel wires into the skin on both sides of the receptor.Investigation of semithin and ultrathin serial sections by light and electron microscopy revealed beneath each cold spot a dermal papilla which contained a single small myelinated fiber dividing into a number of unmyelinated terminals. Near the epidermis the receptor branches leave their Schwann cell envelope, penetrate the basal lamina of the epithelium, and their tips are invaginated into the cytoplasm of the basal epithelial cells. The basal lamina of the epithelium fuses with that of the receptor axon. The receptor axons contain numerous mitochondria, glycogen particles and a filamentous receptor matrix with vesicles of various sizes.The described structures were absent beneath the warm spots. In addition to the cold receptors, Merkel cell neurite complexes and lamellated encapsulated endings were found that are known to be mechanoreceptors.