The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa.
The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa.
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DOI：
10.3390/antibiotics3040677
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发表时间：
2014-11-26
期刊：
影响因子：
--
通讯作者：
Cole AM
中科院分区：
文献类型：
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作者：
Cole AL;Cole AM
女性生殖道 (FRT) 的粘膜和上层液体是 HIV-1 异性传播的门户。为了不断开发针对 HIV-1 的局部杀微生物剂和粘膜疫苗，了解动态 FRT 粘膜如何参与控制 HIV-1 的传播和感染变得越来越重要。阳离子肽和蛋白质是粘膜表面的主要先天免疫效应分子，并以组合方式相互作用来调节子宫颈和阴道的 HIV-1 感染。虽然阳离子肽和蛋白质历来被归类为抗菌剂或具有其他有益于宿主的作用，但越来越多的此类分子被发现会增强 HIV-1 感染并可能拮抗宿主防御。复杂的环境因素，例如激素波动和/或细菌和病毒混合感染，给实验和结果解释带来了额外的挑战。在 HIV-1 异性传播的背景下，本综述探讨了各种阳离子肽和蛋白质如何参与调节宿主对宫颈阴道粘膜的 HIV-1 防御。
The mucosa and overlying fluid of the female reproductive tract (FRT) are portals for the heterosexual transmission of HIV-1. Toward the ongoing development of topically applied microbicides and mucosal vaccines against HIV-1, it is evermore important to understand how the dynamic FRT mucosa is involved in controlling transmission and infection of HIV-1. Cationic peptides and proteins are the principal innate immune effector molecules of mucosal surfaces, and interact in a combinatorial fashion to modulate HIV-1 infection of the cervix and vagina. While cationic peptides and proteins have historically been categorized as antimicrobial or have other host-benefitting roles, an increasing number of these molecules have been found to augment HIV-1 infection and potentially antagonize host defense. Complex environmental factors such as hormonal fluctuations and/or bacterial and viral co-infections provide additional challenges to both experimentation and interpretation of results. In the context of heterosexual transmission of HIV-1, this review explores how various cationic peptides and proteins participate in modulating host defense against HIV-1 of the cervicovaginal mucosa.