Expressions of poly (ADP-ribose) glycohydrolase (PARG) and membrane type 1 matrix metalloproteinase (MT1-MMP) in colorectal carcinoma
Expressions of poly (ADP-ribose) glycohydrolase (PARG) and membrane type 1 matrix metalloproteinase (MT1-MMP) in colorectal carcinoma
复制标题
聚（ADP-核糖）糖水解酶（PARG）和膜1型基质金属蛋白酶（MT1-MMP）在结直肠癌中的表达
DOI：
10.1007/s11670-010-0186-5
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发表时间：
2010
影响因子：
5.1
通讯作者：
Qiaozhuan Li
中科院分区：
文献类型：
--
作者：
Xian Li;Guang;Yalan Wang;N. J. Fauzee;Qiaozhuan Li
ObjectiveTo investigate the significance of Poly (ADP-ribose) glycolhydrolase (PARG) and membrane type 1 matrix metalloproteinase (MT1-MMP) expressions in human colorectal carcinoma.MethodsImmunohistochemical staining for PARG and MT1-MMP was carried out on colorectal adenoma-carcinoma tissue microarrays containing normal colorectal mucosae, adenoma, adenoma with malignant transformation and adenocarcinoma (total 130 specimens). The expressions of PARG and MT1-MMP in the GLTN [Gallotannin]-treated and GLTN-untreated lovo cells were detected by Western Blot.ResultsPARG expression in adenocarcinoma (83.1%) and adenoma with malignant transformation (66.7%) was significantly higher than that in normal colorectal mucosa (10%) and adenoma (10.5%). Expression of MT1-MMp in normal colorectal mucosa and adenoma was negative, while the expression in adenocarcinoma (80.3%) and adenoma with malignant transformation (72.2%) was high. The expressions of PARG and MT1-MMP in adenocarcinoma with metastasis and in late tumor stages were significantly higher than those in adenocarcinoma with no metastasis and in early tumor stages. Thus, PARG expression shows a positive correlation with the expression of MT1-MMP. The expressions of PARG and MT1-MMP in GLTN-treated lovo cells were weaker than that in GLTN-untreated lovo cells.ConclusionThe expression of PARG was probably related to the development of colorectal carcinoma. PARG may play an important role for the regulation of MT1-MMP expression in colorectal carcinoma.
DOI：
10.1073/pnas.0406182101
发表时间：
2004-12-21
影响因子：
11.1
作者：
Koh, DW;Lawler, AM;Dawson, TM
通讯作者：
Dawson, TM