SEXUAL SELECTION IS INEFFECTUAL OR INHIBITS THE PURGING OF DELETERIOUS MUTATIONS IN DROSOPHILA MELANOGASTER
SEXUAL SELECTION IS INEFFECTUAL OR INHIBITS THE PURGING OF DELETERIOUS MUTATIONS IN DROSOPHILA MELANOGASTER
复制标题
DOI：
10.1111/j.1558-5646.2012.01584.x
复制
发表时间：
2012-07-01
期刊：
影响因子：
3.3
通讯作者：
Rundle, Howard D.
中科院分区：
文献类型：
--
作者：
Arbuthnott, Devin;Rundle, Howard D.
性选择对种群平均健康度的影响尚不清楚，也是一个争论的话题。最近的模型提出，由于繁殖成功可能取决于条件，因此大部分基因组可能是性选择的目标。在这种情况下，降低健康水平以及非性适应性的突变也可能对繁殖成功产生有害影响，这意味着性选择可能有助于清除有害等位基因。我们通过对复制的果蝇种群进行两种改变性选择机会的处理来直接测试这一假设，然后跟踪具有隐性和可见表型效应的六个独立有害等位基因的频率变化。虽然自然选择降低了所有六种突变的频率，但性选择的增加并没有帮助清除其中任何一种突变，而且其中三种突变似乎阻碍了它。求爱和交配对这个物种有有害的影响，而择偶分析表明，与突变的雌性相比，雄性对野生型的求偶和交配行为更多，这为性选择的成本提供了可能的解释。这种成本是否延伸到其他突变（例如，那些缺乏可见表型效应的突变）是未来研究的一个重要课题。
The effects of sexual selection on population mean fitness are unclear and a subject of debate. Recent models propose that, because reproductive success may be condition dependent, much of the genome may be a target of sexual selection. Under this scenario, mutations that reduce health, and thus nonsexual fitness, may also be deleterious with respect to reproductive success, meaning that sexual selection may contribute to the purging of deleterious alleles. We tested this hypothesis directly by subjecting replicate Drosophila melanogaster populations to two treatments that altered the opportunity for sexual selection and then tracked changes in the frequency of six separate deleterious alleles with recessive and visible phenotypic effects. While natural selection acted to decrease the frequency of all six mutations, the addition of sexual selection did not aid in the purging of any of them, and for three of them appears to have hampered it. Courtship and mating have harmful effects in this species and mate choice assays showed that males directed more courtship and mating behavior toward wild-type over mutant females, providing a likely explanation for sexual selection's cost. Whether this cost extends to other mutations (e.g., those lacking visible phenotypic effects) is an important topic for future research.