Effects of measurement error and sampling resolution on estimates of atrial tissue recovery parameters.
Effects of measurement error and sampling resolution on estimates of atrial tissue recovery parameters.
复制标题
测量误差和采样分辨率对心房组织恢复参数估计的影响。
DOI：
10.1114/1.1306343
复制
发表时间：
2000
影响因子：
3.8
通讯作者：
Schuessler,RB
中科院分区：
文献类型：
--
作者：
Kay,MW;Bayly,PV;Schuessler,RB
我们使用实验和模拟数据研究了采样分辨率和测量误差对组织恢复参数估计的影响。动作电位持续时间（APD）是根据在对照和乙酰胆碱灌注期间在犬右心房心内膜（n=8）的250个位点（Δx=3.5mm）记录的单相动作电位来估计的。还使用随机数生成器模拟 APD 分布，然后缩放并过滤至生理值。随着APD采样间隔和测量误差的增加，估计以下参数：平均APD、APD标准差、平均APD梯度、APD梯度标准差、APD波长和APD相关长度。我们发现，以不适当的采样间隔收集的 APD 可能会导致较大的误差，而适当的采样间隔可能比奈奎斯特间隔小 3-6 倍。测量误差水平相对较低的数据也会导致较大的参数误差。测量误差的影响取决于 APD 的标准偏差、采样分辨率和 APD 波长。采样分辨率不足是实验参数估计中最大的误差源。随着相关长度和波长估计值的增加，APD 梯度平均值和标准差的估计值随间距的增加而减小。考虑到恢复的空间复杂性以及相当低的测量误差，仔细选择间隔间隔将产生梯度、相关长度和波长的准确估计。 ©2000 生物医学工程学会.PAC00: 8719Nn, 8719Hh, 0620Dk
We studied the effect of sampling resolution and measurement error on estimates of tissue recovery parameters using experimental and simulated data. Action potential duration (APD) was estimated from monophasic action potentials recorded at 250 sites (Δx=3.5 mm) on the endocardium of the canine right atrium (n=8) during control and acetylcholine perfusion. APD distributions were also simulated using a random number generator, then scaled and filtered to physiological values. The following parameters were estimated at increasing APD sampling interval and measurement error: mean APD, standard deviation of APD, mean APD gradient, standard deviation of APD gradient, APD wavelength, and APD correlation length. We found that large errors can result from APDs collected at inadequate sampling intervals and adequate sampling intervals may be 3–6 times less than the Nyquist interval. Large parameter errors also resulted from data with relatively low levels of measurement error. The effect of measurement error was dependent upon the standard deviation of APD, sampling resolution, and APD wavelength. Inadequate sampling resolution was the largest source of error in experimental parameter estimates. Estimates of mean and standard deviation of APD gradient decreased with spacing as estimates of correlation length and wavelength increased. Careful selection of spacing interval, taking into account the spatial complexity of recovery, as well as considerably low measurement errors will produce accurate estimates of gradients, correlation length, and wavelength. ©2000 Biomedical Engineering Society.PAC00: 8719Nn, 8719Hh, 0620Dk